GENR { RETE|ID 1 FBgn0025724 CLA 1 Gene NAM 1 &bgr;'-coatomer protein GSYM 1 &bgr;'Cop DT 1 25 Nov 05 RESZ 4229 PDOM 2 INTERPRO:IPR001680 == WD-40 repeat DBA 15 FNC 7 ER to Golgi transport CEL 1 COPI vesicle coat CLOC 1 34B9 ALESR 1 REF 12 GSYM|&bgr;'Cop DT|25 Nov 05 ID|FBgn0025724 UAB|Duplication: Dp(2;2)GYL (inferred from cytology) SYN|CG6699 |CG6699 |beta'-COP |d&bgr;'COP |beta'Cop NAM|&bgr;'-coatomer protein CLOC|34B9 |Limits computationally determined from genome sequence between @P{lacW}l(2)k00302k00302@ and @P{PZ}kuz03782@&@P{lacW}kuzk14817@ CYC|Experimentally determined: 34B5--9 FNC|ER to Golgi transport ; GO:0006888 |Golgi vesicle budding ; GO:0048194 |cell surface receptor linked signal transduction ; GO:0007166 |endocytosis ; GO:0006897 |exocytosis ; GO:0006887 |intracellular protein transport ; GO:0006886 |retrograde transport, Golgi to ER ; GO:0006890 CEL|COPI vesicle coat ; GO:0030126 PDOM|IPR001680 == WD-40 repeat |IPR006692 == Coatomer WD associated region ENZ|protein transporter activity ; GO:0008565 |protein transporter activity ; GO:0008565 | inferred from electronic annotation DBA|NA:AA264134 |BDGP:LD07733 |NA:AE003639 |PA:AAF53294 |NA:AI293311 |BDGP-DGC:GH16479 |NA:AJ006523 |PA:CAA07084 |NA:AJ006524 |PA:CAA07085 |NA:AW940627 |BDGP-DGC:GH16479 |NA:AY119527 |PA:AAM50181 |BDGP-DGC:GH16479 PAC|UniProt_Swiss_Prot:O62621 ASQ|FBan0006699 REF { REFM|FBrf0106031 |Merdes |1998.12.20 |9 REFM|FBrf0118012 |Merdes |1998.6.2 |9 REFM|FBrf0118011 |Merdes |1998.6.2 |9 REFM|FBrf0146969 |Dunne et al. |2002 |0 REFM|FBrf0126702 |Zheng |1999.11 |9 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0161459 |Mi et al. |2003.9.9 |9 REFM|FBrf0166452 |Giot et al. |2003 |9 REFM|FBrf0126671 |Guan |1999.11 |9 REFM|FBrf0131779 |Swiss-Prot Project Members |2000.10.1 |9 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0174215 |FlyBase Curators et al. |2004- |9 } REFDSR { RDID|FBrf0106031 |Merdes |1998.12.20 CLOC|34B5--9 (determined by in situ hybridization) } REFDSR { RDID|FBrf0118011 |Merdes |1998.6.2 FNC|ER to Golgi transport ; GO:0006888 | non-traceable author statement |Golgi vesicle budding ; GO:0048194 | non-traceable author statement |retrograde transport, Golgi to ER ; GO:0006890 | non-traceable author statement CEL|COPI vesicle coat ; GO:0030126 | non-traceable author statement SYN|beta'-COP } REFDSR { RDID|FBrf0118012 |Merdes |1998.6.2 FNC|retrograde transport, Golgi to ER ; GO:0006890 | non-traceable author statement CEL|COPI vesicle coat ; GO:0030126 | non-traceable author statement GPD|coatomer, &bgr;'-subunit SYN|beta'-COP } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: GH16479 (BDGP-DGC) } REFDSR { RDID|FBrf0126671 |Guan |1999.11 AM|Source for identity of: &bgr;'Cop CG6699 } REFDSR { RDID|FBrf0131779 |Swiss-Prot Project Members |2000.10.1 FNC|retrograde transport, Golgi to ER ; GO:0006890 | non-traceable author statement CEL|COPI vesicle coat ; GO:0030126 | non-traceable author statement } REFDSR { RDID|FBrf0146969 |Dunne et al. |2002 MD|Identified with: LD07733 SYN|CG6699 |d&bgr;'COP } REFDSR { RDID|FBrf0161459 |Mi et al. |2003.9.9 FNC|cell surface receptor linked signal transduction ; GO:0007166 | inferred from electronic annotation |endocytosis ; GO:0006897 | inferred from electronic annotation |exocytosis ; GO:0006887 | inferred from electronic annotation |intracellular protein transport ; GO:0006886 | inferred from electronic annotation } REFDSR { RDID|FBrf0166452 |Giot et al. |2003 SYN|beta'Cop } REFDSR { RDID|FBrf0174215 |FlyBase Curators et al. |2004- ENZ|protein transporter activity ; GO:0008565 | inferred from electronic annotation FNC|intracellular protein transport ; GO:0006886 | inferred from electronic annotation } ALESR { ASYM|&bgr;'Cop+ ID|FBal0093738 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0070058 CLA 1 foreign safe element NAM 1 attP recombination target site GSYM 1 &lgr;\attP DT 1 25 Nov 05 RESZ 1048 FSQ 1 Bacteriophage lambda attP', recombination target site'. ALESR 2 REF 1 GSYM|&lgr;\attP DT|25 Nov 05 ID|FBgn0070058 CLA|foreign_safe_element NAM|attP recombination target site FSQ|species == Bacteriophage lambda; sequence == attP', recombination target site'. OTH|The @T:&lgr;\&lgr;@ recombination proteins mediate site-specific and |directional recombination between recombination sites; |@Ecol\attB@ x @&lgr;\attP@ <=> @Ecol\attL@ and @Ecol\attR@. REF { REFM|FBrf0179058 |Murphy |2003- |9 } ALESR { ASYM|&lgr;\attP1 SYN|attP1 ID|FBal0157551 REF|FBrf0179058 REFDSR { RDID|FBrf0179058 |Murphy |2003- OTH|@Ecol\attR1@ will recombine with @Ecol\attL1@ to produce @Ecol\attB1@ |and @&lgr;\attP1@. SYN|attP1 } } ALESR { ASYM|&lgr;\attP2 SYN|attP2 ID|FBal0157550 REF|FBrf0179058 REFDSR { RDID|FBrf0179058 |Murphy |2003- OTH|@Ecol\attR2@ will recombine with @Ecol\attL2@ to produce @Ecol\attB2@ |and @&lgr;\attP2@. SYN|attP2 } } } # EOR GENR { RETE|ID 1 FBgn0043467 CLA 1 Gene NAM 1 064Ya GSYM 1 064Ya DT 1 25 Nov 05 RESZ 1309 FNC 1 behavioral response to ethanol CEL 1 cellular component unknown CLOC 1 XLt--XRt ALESR 2 REF 2 GSYM|064Ya DT|25 Nov 05 ID|FBgn0043467 NAM|064Ya FNC|behavioral response to ethanol ; GO:0048149 CEL|cellular component unknown ; GO:0008372 CLOC|XLt--XRt ENZ|molecular function unknown ; GO:0005554 |molecular function unknown ; GO:0005554 | no biological data available REF { REFM|FBrf0159398 |FlyBase Curators |2002- |9 REFM|FBrf0131396 |Scholz et al. |2000 |0 } REFDSR { RDID|FBrf0131396 |Scholz et al. |2000 CLOC|XLt--XRt FNC|behavioral response to ethanol ; GO:0048149 | inferred from mutant phenotype SYN|unnamed } REFDSR { RDID|FBrf0159398 |FlyBase Curators |2002- ENZ|molecular function unknown ; GO:0005554 | no biological data available CEL|cellular component unknown ; GO:0008372 | no biological data available } ALESR { ASYM|064Ya064Ya SYN|064Y ID|FBal0119724 PHC|chemical sensitive PHI|Mutants exhibit a reduced tolerance to ethanol. REF|FBrf0131396 REFDSR { RDID|FBrf0131396 |Scholz et al. |2000 TRN|FBti0016904 == P{GAL4}064Ya064Ya MU|P-element activity PHC|chemical sensitive PHI|Mutants exhibit a reduced tolerance to ethanol. SYN|064Y } } ALESR { ASYM|064Ya+ ID|FBal0120253 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0010347 CLA 1 Gene NAM 1 1.28 GSYM 1 1.28 DT 1 25 Nov 05 RESZ 5894 PDOM 1 INTERPRO:IPR000194 == H+-transporting two-sector ATPase, alpha/beta subunit, central region PTD 1 DBA 4 FNC 2 ATP synthesis coupled proton transport CEL 1 proton-transporting two-sector ATPase complex CLOC 1 42B3 ALESR 3 REF 19 GSYM|1.28 PTD DT|25 Nov 05 ID|FBgn0010347 UAB|Deficiency: Df(2R)cn88b (inferred from cytology) |Duplication: Dp(2;Y)cn+ (inferred from cytology) SYN|CG9397 |CG9397 |CG9397 |deformed |CT9093 NAM|1.28 CLOC|42B3 |Limits computationally determined from genome sequence between @P{lacW}l(2)k09848k09848@&@P{EP}EP407@ and @P{lacW}geminink14019@&@P{PZ}Adf101349@ CYC|Experimentally determined: 42B FNC|ATP synthesis coupled proton transport ; GO:0015986 |specification of segmental identity, maxillary segment ; GO:0007382 CEL|proton-transporting two-sector ATPase complex ; GO:0016469 PDOM|IPR000194 == H+-transporting two-sector ATPase, alpha/beta subunit, central region ENZ|ATP binding ; GO:0005524 |ATP binding ; GO:0005524 | inferred from electronic annotation |hydrogen-transporting ATP synthase activity, rotational mechanism ; GO:0046933 |hydrogen-transporting ATPase activity, rotational mechanism ; GO:0046961 |hydrogen-transporting ATP synthase activity, rotational mechanism ; GO:0046933 | inferred from electronic annotation |hydrogen-transporting ATPase activity, rotational mechanism ; GO:0046961 | inferred from electronic annotation DBA|NA:AE003789 |PA:AAF57355 |NA:L07262 |PA:AAA03084 PAC|UniProt_TrEMBL:Q24300 |UniProt_TrEMBL:Q9V9D6 WTI|Dfd ASQ|FBan0009397 REF { REFM|FBrf0132330 |Mahaffey et al. |2001 |0 REFM|FBrf0064596 |Mahaffey et al. |1993 |0 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0075267 |Mahaffey |1993 |9 REFM|FBrf0079168 |Pederson and Mahaffey |1995 |1 REFM|FBrf0085725 |Pederson et al. |1996 |1 REFM|FBrf0152147 |Ceriani et al. |2002 |0 REFM|FBrf0179413 |Robertson et al. |2004 |0 REFM|FBrf0090735 |Pederson et al. |1996 |0 REFM|FBrf0117645 |Mahaffey |1992 |9 REFM|FBrf0174215 |FlyBase Curators et al. |2004- |9 REFM|FBrf0092336 |LaFollette et al. |1997 |1 REFM|FBrf0136026 |Dobie and Karpen |2001.4.18 |9 REFM|FBrf0130258 |Pederson et al. |2000 |0 REFM|FBrf0068222 |Mahaffey et al. |1994 |1 REFM|FBrf0078949 |Mahato and Mahaffey |1995 |1 REFM|FBrf0068424 |Botas |1993 |2 REFM|FBrf0076134 |Mohler et al. |1995 |0 REFM|FBrf0137489 |Mount |2001.8.14 |9 } REFDSR { RDID|FBrf0064596 |Mahaffey et al. |1993 CLOC|42B (determined by in situ hybridization) FNC|specification of segmental identity, maxillary segment ; GO:0007382 | inferred from expression pattern |specification of segmental identity, maxillary segment ; GO:0007382 | inferred from genetic interaction with FLYBASE:Dfd; FB:FBgn0000439 WT|Identified in an enhancer trap screen for target genes of homeoproteins. |The 1.28 gene is a target gene that is activated by @Dfd@. @Dfd@ is required |to activate 1.28 in the maxillary segment, but ectopic expression of |@Dfd@ is incapable of activating @1.28@ elsewhere. WTI|Dfd } REFDSR { RDID|FBrf0079168 |Pederson and Mahaffey |1995 WT|The @1.28@ gene is directly activated by @Dfd@ in the maxillary segment |but not in the mandibular segment. Four @Dfd@-product binding sites |have been identified within a 664bp fragment of the @1.28@ regulatory |region, in addition to a @Dfd@ epidermal autoactivation element (DEAE). WTI|Dfd } REFDSR { RDID|FBrf0105495 |FlyBase |1992- } REFDSR { RDID|FBrf0117645 |Mahaffey |1992 CLOC|42B SYN|deformed } REFDSR { RDID|FBrf0136026 |Dobie and Karpen |2001.4.18 AM|"1.28" may correspond to "Scim21". |Sequence analysis off ends of @P{SUPor-P}@ in Scim insertion mutant |places "Scim21" near/in "1.28". SYN|CG9397 } REFDSR { RDID|FBrf0137489 |Mount |2001.8.14 SYN|CG9397 } REFDSR { RDID|FBrf0152147 |Ceriani et al. |2002 SYN|CT9093 } REFDSR { RDID|FBrf0174215 |FlyBase Curators et al. |2004- ENZ|ATP binding ; GO:0005524 | inferred from electronic annotation |hydrogen-transporting ATP synthase activity, rotational mechanism ; GO:0046933 | inferred from electronic annotation |hydrogen-transporting ATPase activity, rotational mechanism ; GO:0046961 | inferred from electronic annotation FNC|ATP synthesis coupled proton transport ; GO:0015986 | inferred from electronic annotation CEL|proton-transporting two-sector ATPase complex ; GO:0016469 | inferred from electronic annotation } REFDSR { RDID|FBrf0179413 |Robertson et al. |2004 } ALESR { ASYM|1.28P ID|FBal0121022 REF|FBrf0130258 REFDSR { RDID|FBrf0130258 |Pederson et al. |2000 MD|@P{lacW}@ insertion into the @Deaf1@ binding region of the @1.28@ regulatory |sequences. TRN|FBti0003587 == P{lacW}1.28P MU|P-element activity } } ALESR { ASYM|1.28rv13 SYN|line 13 ID|FBal0121021 REF|FBrf0130258 REFDSR { RDID|FBrf0130258 |Pederson et al. |2000 MD|Mobilization of the @P{lacW}@ element, resulting in a deletion of approximately |1kb upstream of the original @P{lacW}@ element insertion site. PRG|1.28P MU|&Dgr;2-3 SYN|line 13 } } ALESR { ASYM|1.28+ ID|FBal0066314 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0026615 CLA 1 Gene NAM 1 10-4 GSYM 1 10-4 DT 1 25 Nov 05 RESZ 1762 FNC 1 biological process unknown CEL 2 apical part of cell ALESR 1 REF 2 GSYM|10-4 DT|25 Nov 05 ID|FBgn0026615 NAM|10-4 FNC|biological process unknown ; GO:0000004 CEL|apical part of cell ; GO:0045177 |cytoplasm ; GO:0005737 MD|In dividing precursor cells of the developing nervous system the |correct asymmetric apical localization of @10-4@ mRNA depends on |@insc@. @10-4@ protein localization to the apical cytoplasm occurs |when @insc@ protein disappears, in anaphase. In telophase @10-4@ |protein forms a tight apical crescent. ENZ|molecular function unknown ; GO:0005554 |molecular function unknown ; GO:0005554 | no biological data available REF { REFM|FBrf0159398 |FlyBase Curators |2002- |9 REFM|FBrf0106275 |Bulgheresi and Knoblich |1999 |1 } REFDSR { RDID|FBrf0106275 |Bulgheresi and Knoblich |1999 MD|In dividing precursor cells of the developing nervous system the |correct asymmetric apical localization of @10-4@ mRNA depends on |@insc@. @10-4@ protein localization to the apical cytoplasm occurs |when @insc@ protein disappears, in anaphase. In telophase @10-4@ |protein forms a tight apical crescent. CEL|apical part of cell ; GO:0045177 | inferred from direct assay |cytoplasm ; GO:0005737 | inferred from direct assay OTH|Identification: Defined in a yeast two hybrid assay for genes whose |products interact with the 364 amino acid domain of @insc@ that |are required and sufficient for all the known @insc@ functions. } REFDSR { RDID|FBrf0159398 |FlyBase Curators |2002- ENZ|molecular function unknown ; GO:0005554 | no biological data available FNC|biological process unknown ; GO:0000004 | no biological data available } ALESR { ASYM|10-4+ ID|FBal0096586 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0067637 CLA 1 Gene NAM 1 106y GSYM 1 106y DT 1 25 Nov 05 RESZ 2199 ALESR 2 REF 1 GSYM|106y DT|25 Nov 05 ID|FBgn0067637 NAM|106y REF { REFM|FBrf0141372 |Ejima et al. |2001 |0 } ALESR { ASYM|106y106y SYN|106y ID|FBal0151008 PHC|viable |fertile |courtship defective | female PHI|@106y106y@ virgin females show elevated ovulation; 27% of the virgin |females show ovulation (compared to 0% of virgin Oregon-R females). |The flies show no obvious defects in viability, fertility, morphology |or locomotor activity. |The courtship index observed when @106y106y@ virgin females are mated |to wild-type males is lower than that seen when wild-type virgin females |are mated to wild-type males, but is higher than that seen when wild-type |mated females are mated to wild-type males. @106y106y@ mutant virgin |females show ovipositor extrusion towards courting wild-type males |(this extrusion behavior is normally observed in mated wild-type females |but not in virgin wild-type females). REF|FBrf0141372 REFDSR { RDID|FBrf0141372 |Ejima et al. |2001 TRN|FBti0037977 == P{GawB}106y106y MU|P-element activity PHC|viable |fertile |courtship defective | female PHI|@106y106y@ virgin females show elevated ovulation; 27% of the virgin |females show ovulation (compared to 0% of virgin Oregon-R females). |The flies show no obvious defects in viability, fertility, morphology |or locomotor activity. |The courtship index observed when @106y106y@ virgin females are mated |to wild-type males is lower than that seen when wild-type virgin females |are mated to wild-type males, but is higher than that seen when wild-type |mated females are mated to wild-type males. @106y106y@ mutant virgin |females show ovipositor extrusion towards courting wild-type males |(this extrusion behavior is normally observed in mated wild-type females |but not in virgin wild-type females). SYN|106y } } ALESR { ASYM|106y+ ID|FBal0151314 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0011557 CLA 1 Gene NAM 1 107.1 GSYM 1 107.1 DT 1 25 Nov 05 RESZ 1158 ALESR 1 REF 3 GSYM|107.1 DT|25 Nov 05 ID|FBgn0011557 NAM|107.1 WTI|tub REF { REFM|FBrf0068202 |West and Anderson |1994 |1 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0079611 |West and Anderson |1995 |1 } REFDSR { RDID|FBrf0068202 |West and Anderson |1994 WTI|tub PHP|@107.1@ behaves as a dominant gain of function enhancer of all alleles |of @tub@, @107.1@ regulates @tub@ at post-transcriptional level. @107.1@ |acts in trans to disrupt accumulation of maternal @tub@ transcript. |Females homozygous for @107.1@ lack maternal @tub@ transcript and |yield completely dorsalized embryos. } REFDSR { RDID|FBrf0079611 |West and Anderson |1995 PHP|@107.1@ may define a regulator of @tub@ transcript levels, the recessive |maternal effect dorsalizing mutation exhibits loss of @tub@ message |that can be completely rescued with excess @tub@. } ALESR { ASYM|107.1+ ID|FBal0066315 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0070057 CLA 1 Gene NAM 1 11 GSYM 1 11 DT 1 25 Nov 05 RESZ 968 FNC 1 eye photoreceptor cell differentiation CEL 1 cellular component unknown ALESR 1 REF 2 GSYM|11 DT|25 Nov 05 ID|FBgn0070057 SYN|#1 NAM|11 FNC|eye photoreceptor cell differentiation ; GO:0001754 CEL|cellular component unknown ; GO:0008372 ENZ|molecular function unknown ; GO:0005554 |molecular function unknown ; GO:0005554 | no biological data available REF { REFM|FBrf0173481 |Pistillo et al. |2004 |1 REFM|FBrf0159398 |FlyBase Curators |2002- |9 } REFDSR { RDID|FBrf0159398 |FlyBase Curators |2002- ENZ|molecular function unknown ; GO:0005554 | no biological data available CEL|cellular component unknown ; GO:0008372 | no biological data available } REFDSR { RDID|FBrf0173481 |Pistillo et al. |2004 FNC|eye photoreceptor cell differentiation ; GO:0001754 | inferred from mutant phenotype OTH|Identification: In a screen for mutations affecting R7/R8 photoreceptor subtype specification. SYN|#1 } ALESR { ASYM|11+ ID|FBal0158438 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0010339 CLA 1 Gene NAM 1 upstream of RpIII128 GSYM 1 128up DT 1 25 Nov 05 RESZ 4781 PDOM 5 INTERPRO:IPR002917 == GTP-binding protein, HSR1-related PTD 1 DBA 10 CLOC 1 48D8 ALESR 1 REF 14 GSYM|128up PTD MMP DT|25 Nov 05 ID|FBgn0010339 UAB|Duplication: Dp(2;2)Y3b (inferred from cytology) SYN|CG8340 |CG8340 |GTP-bp |X71866 ID2|FBgn0010196 NAM|upstream of RpIII128 GLOC|2- CLOC|48D8 |Limits computationally determined from genome sequence between @P{lacW}l(2)k06612k06612@ and @P{lacW}jebk05644@ CYC|Experimentally determined: 48E PDOM|IPR002917 == GTP-binding protein, HSR1-related |IPR004095 == TGS |IPR005225 == Small GTP-binding protein domain |IPR006073 == GTP1/OBG |IPR006074 == GTP1/OBG domain MD|Identified with: SD05004 (BDGP-DGC) ENZ|GTP binding ; GO:0005525 |GTP binding ; GO:0005525 | inferred from direct assay |GTP binding ; GO:0005525 | non-traceable author statement |hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides ; GO:0016818 ; EC:3.6.1.- | inferred from electronic annotation |hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides ; GO:0016818 ; EC:3.6.1.- |GTP binding ; GO:0005525 | inferred from sequence similarity with UniProt:P43690 DBA|NA:AE003823 |PA:AAF58591 |NA:AI533247 |BDGP-DGC:SD05004 |NA:AX093898 |NA:AY069810 |PA:AAL39955 |BDGP-DGC:SD05004 |NA:X71866 |PA:CAA50701 PAC|UniProt_Swiss_Prot:P32234 ASQ|FBan0008340 REF { REFM|FBrf0067209 |Sommer et al. |1994 |0 REFM|FBrf0102347 |Kliman and Eyre-Walker |1998 |0 REFM|FBrf0126686 |Milshina |1999.11 |9 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 REFM|-1505380982 |0 |Patent: WO 0118547-A 15-MAR-2001; REFM|FBrf0058389 |Sommer et al. |1993 |1 REFM|FBrf0147137 |Brody et al. |2002 |0 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0146674 |Roth and Foulger |2002.4.24 |9 REFM|FBrf0155515 |Ptak and Petrov |2002 |0 REFM|FBrf0166452 |Giot et al. |2003 |9 REFM|FBrf0156694 |Swiss-Prot Project Members |1993.10.1 |9 REFM|FBrf0090923 |Seifarth |1991 |9 REFM|FBrf0105495 |FlyBase |1992- |9 } REFDSR { RDID|FBrf0058389 |Sommer et al. |1993 WT|@RpIII128@ gene is flanked by an upstream transcription unit, @128up@. |@128up@ is transcribed in the same direction as @RpIII128@ and they |are separated by a short intergenic region. Bacterially expressed |@128up@, in fusion with maltose binding protein (MBP), specifically |binds GTP. } REFDSR { RDID|995280021 |Davies |2001.3.30 OTH|Area matching Drosophila GTP-binding protein, Acc. No. X71866. } REFDSR { RDID|FBrf0067209 |Sommer et al. |1994 ENZ|GTP binding ; GO:0005525 | inferred from direct assay WT|Bacterially expressed @128up@ is capable of binding GTP and the protein |is primarily located in the perinuclear region. GPD|GTP binding protein } REFDSR { RDID|FBrf0090923 |Seifarth |1991 CLOC|48E (determined by in situ hybridization) } REFDSR { RDID|FBrf0102347 |Kliman and Eyre-Walker |1998 OTH|In a sample of 79 genes with multiple introns, 33 showed significant |heterogeneity in G+C content among introns of the same gene and significant |positive correspondence between the intron and the third codon position |G+C content within genes. These results are consistent with selection |adding against preferred codons at the start of genes. SYN|GTP-bp } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|GTP binding ; GO:0005525 | inferred from sequence similarity with UniProt:P43690 } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: SD05004 (BDGP-DGC) } REFDSR { RDID|FBrf0146674 |Roth and Foulger |2002.4.24 ENZ|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides ; GO:0016818 ; EC:3.6.1.- | inferred from electronic annotation } REFDSR { RDID|FBrf0147137 |Brody et al. |2002 SYN|CG8340 } REFDSR { RDID|FBrf0155515 |Ptak and Petrov |2002 SYN|X71866 } REFDSR { RDID|FBrf0156694 |Swiss-Prot Project Members |1993.10.1 ENZ|GTP binding ; GO:0005525 | non-traceable author statement } REFDSR { RDID|FBrf0166452 |Giot et al. |2003 } ALESR { ASYM|128up+ ID|FBal0066316 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0005673 CLA 1 transposable element NAM 1 1360 element GSYM 1 1360 DT 1 25 Nov 05 RESZ 9429 DBA 19 WT 5 In situ hybridization to polytene chromosomes shows variable REF 55 GSYM|1360 MMP DT|25 Nov 05 ID|FBgn0005673 CLA|transposable_element SYN|hoppel |hopel |Hoppel |hoppel-like |Dr. D |protop |protop_b |Hoppel-like |DmHoppel |ProtoP |ProtoP_B |1360/Hoppel |Dm1360 |EG:23E12.4 |anon-CH(3)336 |CR31276 |CR31011 |CR31553 ID2|FBgn0004180 |FBgn0013399 |FBgn0051011 |FBgn0051276 |FBgn0051553 NAM|1360 element TE|element type: IR |terminal repeat length in bp: 37 |total length in bp: 1176 |target site duplication length in bp: 6 |number of copies in genome: >25 WT|In situ hybridization to polytene chromosomes shows variable, |strain-specific location in the euchromatic parts of the arms and heavy |labeling of the 12E region of the X chromosome, chromosome bases |(20A--20F, 40A--40F, 41A--41F, 80A--80C and 81F), the chromocenter and |chromosome 4. DBA|NA:AF533772 |NA:AF540061 |NA:AJ000473 |NA:AJ441085 |NA:AL031884 |NA:AY138841 |NA:L36596 |NA:M55078 |NA:U66884 |NA:X59157 |NA:X78388 |NA:Z11734 |NA:Z11735 |NA:Z31905 |dbSTS:4444 |NA:Z32073 |dbSTS:4624 |NA:Z32074 |dbSTS:4625 ASQ|FBan0031276 REF { REFM|FBrf0160656 |Kapitonov and Jurka |2003 |0 REFM|FBrf0111489 |Spradling et al. |1999 |0 REFM|FBrf0134799 |van Steensel et al. |2001 |9 REFM|FBrf0155828 |Kaminker et al. |2002 |0 REFM|FBrf0053529 |Leibovich et al. |1991 |0 REFM|FBrf0053528 |Leibovich |1991 |0 REFM|FBrf0159203 |Reiss et al. |2003 |0 REFM|FBrf0155823 |Celniker et al. |2002 |0 REFM|FBrf0162162 |Lerat et al. |2003 |0 REFM|FBrf0105803 |Cryderman et al. |1998 |0 REFM|FBrf0155500 |Maggert and Golic |2002 |0 REFM|FBrf0144916 |Rizzon et al. |2002 |0 REFM|FBrf0071734 |EDGP Project Members |1994- |9 REFM|FBrf0046087 |Kholodilov et al. |1987 |0 REFM|FBrf0105798 |Coelho et al. |1998 |0 REFM|FBrf0149015 |Yan et al. |2002 |0 REFM|FBrf0106872 |Locke et al. |1999 |9 REFM|FBrf0151607 |Kapitonov and Jurka |1997- |9 REFM|FBrf0137315 |Galindo et al. |2001 |0 REFM|FBrf0106421 |Dimitri et al. |1999 |1 REFM|FBrf0080514 |Zhang and Spradling |1995 |0 REFM|FBrf0080225 |Madueno et al. |1995 |0 REFM|FBrf0135796 |Pardue and Debaryshe |2000 |2 REFM|FBrf0149106 |Bartolome et al. |2002 |0 REFM|FBrf0125039 |Bejarano and Gonzalez |1999 |0 REFM|FBrf0135794 |Wallrath |2000 |2 REFM|FBrf0167608 |Greil et al. |2003 |0 REFM|FBrf0135792 |Gvozdev et al. |2000 |2 REFM|FBrf0162058 |Aravin et al. |2003 |0 REFM|FBrf0123109 |Locke et al. |1999 |0 REFM|FBrf0128554 |Locke et al. |2000 |0 REFM|FBrf0101830 |Locke et al. |1998 |1 REFM|FBrf0083001 |Almeida Coelho and Sunkel |1995 |1 REFM|FBrf0052018 |Kurenova et al. |1990 |0 REFM|FBrf0057400 |Balakireva et al. |1992 |0 REFM|FBrf0174713 |Myster et al. |2004 |0 REFM|FBrf0126011 |Aravin et al. |2000 |1 REFM|FBrf0137496 |Misra |2001.8.16 |9 REFM|FBrf0182932 |Hodgetts |2004 |2 REFM|FBrf0151627 |Ashburner |2002.8.15 |9 REFM|FBrf0135823 |Benos et al. |2001 |0 REFM|FBrf0047691 |Kholodilov et al. |1988 |0 REFM|FBrf0117093 |Kurenova |1994.5.6 |9 REFM|FBrf0112417 |Ahmed |1996.8.14 |9 REFM|FBrf0121135 |Sunkel |1997.7.15 |9 REFM|FBrf0109548 |Cryderman et al. |1999 |0 REFM|FBrf0101859 |Wallrath et al. |1998 |1 REFM|FBrf0100583 |Kalmykova et al. |1998 |0 REFM|FBrf0151719 |Tulin et al. |2002 |0 REFM|FBrf0117473 |Livak |1992.2.24 |9 REFM|FBrf0117472 |Livak |1992.2.24 |9 REFM|FBrf0158933 |Marsano et al. |2003 |0 REFM|FBrf0158965 |Tritto et al. |2003 |0 REFM|FBrf0137199 |Aravin et al. |2001 |0 REFM|FBrf0099762 |Deak et al. |1997 |0 } REFDSR { RDID|FBrf0047691 |Kholodilov et al. |1988 WT|In situ hybridization to polytene chromosomes shows variable, |strain-specific location in the euchromatic parts of the arms and heavy |labeling of the 12E region of the X chromosome, chromosome bases |(20A--20F, 40A--40F, 41A--41F, 80A--80C and 81F), the chromocenter and |chromosome 4. } REFDSR { RDID|FBrf0052018 |Kurenova et al. |1990 PHP|A @1360@ element has been cloned and sequenced. It is flanked by short |inverted repeats. The @1360@ element is present in approximately 10-30 |euchromatic sites and also in numerous heterochromatic sites (in the |chromocenter, pericentric heterochromatin, the fourth chromosome and |at the telomeres) in the D.melanogaster genome. At least 6 variant |@1360@ elements differing in the length of the central region have |been detected. The @1360@ element has ARS activity, similar to the |@P-element@. SYN|hoppel } REFDSR { RDID|FBrf0053528 |Leibovich |1991 SYN|hopel } REFDSR { RDID|FBrf0053529 |Leibovich et al. |1991 SYN|hopel } REFDSR { RDID|FBrf0080514 |Zhang and Spradling |1995 } REFDSR { RDID|FBrf0083001 |Almeida Coelho and Sunkel |1995 SYN|Hoppel } REFDSR { RDID|FBrf0099762 |Deak et al. |1997 SYN|hoppel } REFDSR { RDID|FBrf0101830 |Locke et al. |1998 SYN|Hoppel } REFDSR { RDID|FBrf0101859 |Wallrath et al. |1998 SYN|hoppel } REFDSR { RDID|FBrf0105803 |Cryderman et al. |1998 SYN|hoppel } REFDSR { RDID|FBrf0106421 |Dimitri et al. |1999 SYN|hoppel } REFDSR { RDID|FBrf0106872 |Locke et al. |1999 SYN|Hoppel } REFDSR { RDID|FBrf0109548 |Cryderman et al. |1999 SYN|hoppel } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 SYN|hoppel } REFDSR { RDID|FBrf0112417 |Ahmed |1996.8.14 SYN|unnamed } REFDSR { RDID|FBrf0117093 |Kurenova |1994.5.6 SYN|hoppel } REFDSR { RDID|FBrf0117472 |Livak |1992.2.24 SYN|unnamed } REFDSR { RDID|FBrf0117473 |Livak |1992.2.24 SYN|unnamed } REFDSR { RDID|FBrf0121135 |Sunkel |1997.7.15 SYN|hoppel-like } REFDSR { RDID|FBrf0123109 |Locke et al. |1999 TE|The "Dr. D" repetitive sequence (described in FBrf0048918) contains |sequences of both @INE-1@ and @1360@ transposable elements. SYN|hoppel } REFDSR { RDID|FBrf0125039 |Bejarano and Gonzalez |1999 SYN|hoppel } REFDSR { RDID|FBrf0126011 |Aravin et al. |2000 SYN|hoppel } REFDSR { RDID|FBrf0128554 |Locke et al. |2000 SYN|Dr. D |Hoppel } REFDSR { RDID|FBrf0134799 |van Steensel et al. |2001 SYN|hoppel } REFDSR { RDID|FBrf0135792 |Gvozdev et al. |2000 SYN|hoppel } REFDSR { RDID|FBrf0135794 |Wallrath |2000 SYN|hoppel } REFDSR { RDID|FBrf0135796 |Pardue and Debaryshe |2000 SYN|Hoppel } REFDSR { RDID|FBrf0137199 |Aravin et al. |2001 SYN|hoppel } REFDSR { RDID|FBrf0144916 |Rizzon et al. |2002 SYN|Hoppel } REFDSR { RDID|FBrf0151607 |Kapitonov and Jurka |1997- SYN|protop |protop_b } REFDSR { RDID|FBrf0151719 |Tulin et al. |2002 SYN|hoppel } REFDSR { RDID|FBrf0155500 |Maggert and Golic |2002 SYN|hoppel } REFDSR { RDID|FBrf0155828 |Kaminker et al. |2002 TE|element type: IR |total length in bp: 1177 |number of copies in genome: 105 in euchromatin of Release 3 genome annotation, of which 10 are full length. } REFDSR { RDID|FBrf0158933 |Marsano et al. |2003 SYN|Hoppel-like |DmHoppel } REFDSR { RDID|FBrf0158965 |Tritto et al. |2003 SYN|Hoppel } REFDSR { RDID|FBrf0160656 |Kapitonov and Jurka |2003 TE|total length in bp: 4480 |number of copies in genome: 17 SYN|ProtoP |ProtoP_B } REFDSR { RDID|FBrf0162058 |Aravin et al. |2003 } REFDSR { RDID|FBrf0162162 |Lerat et al. |2003 SYN|hoppel } REFDSR { RDID|FBrf0167608 |Greil et al. |2003 } REFDSR { RDID|FBrf0174713 |Myster et al. |2004 SYN|1360/Hoppel } REFDSR { RDID|FBrf0182932 |Hodgetts |2004 SYN|hoppel } } # EOR GENR { RETE|ID 1 FBgn0066320 CLA 1 transposable element gene NAM 1 T GSYM 1 1360\T DT 1 25 Nov 05 RESZ 317 DBA 2 ALESR 1 REF 1 GSYM|1360\T DT|25 Nov 05 ID|FBgn0066320 CLA|transposable_element_gene NAM|T AM|encoded by: @1360@ DBA|NA:AF533772 |PA:AAN39288 PAC|UniProt_TrEMBL:Q86BW1 REF { REFM|FBrf0159203 |Reiss et al. |2003 |0 } ALESR { ASYM|1360\T+ ID|FBal0146588 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0020238 CLA 1 Gene NAM 1 14-3-3&egr; GSYM 1 14-3-3&egr; DT 1 25 Nov 05 RESZ 38932 PDOM 1 INTERPRO:IPR000308 == 14-3-3 protein PTD 1 DBA 20 FNC 10 DNA damage checkpoint CEL 4 chromosome WT 2 @14-3-3&egr;@ is required to time mitosis in undisturbed post-blastoderm CLOC 1 90F10 ALESR 17 SK 6 REF 61 GSYM|14-3-3&egr; PTD ARGS DT|25 Nov 05 ID|FBgn0020238 UAB|Deficiency: Df(3R)P14 |Duplication: Dp(3;3)C123.3 (inferred from cytology) SYN|CG31196 |SR3-9 |Suppressor of Ras85D 3-9 |14-3-3 |d14-3-3&egr; |14-3-3epsilon |14-3-3e |CT24092 |EK3-5 |D14-3-3&egr; |14-3-3-e |D14-3-3e |par-5 |Par-5 |PAR5 |anon-WO0172774.141 |anon-WO02059370.52 |Su(Raf)3B |l(3)j2B10 ID2|FBgn0011329 |FBgn0016739 |FBgn0016743 |FBgn0046456 |FBgn0051196 |FBgn0064146 |FBgn0066007 NAM|14-3-3&egr; CLOC|90F10 |Limits computationally determined from genome sequence between @P{EP}cpoEP3679@ and @P{EP}Dlc90FEP3634@ CYC|Experimentally determined: 90E--F, 90F6--7 FNC|DNA damage checkpoint ; GO:0000077 |Ras protein signal transduction ; GO:0007265 |imaginal disc development ; GO:0007444 |maintenance of oocyte identity (sensu Insecta) ; GO:0016350 |mitotic checkpoint ; GO:0007093 |nonassociative learning ; GO:0046958 |oocyte microtubule cytoskeleton polarization (sensu Insecta) ; GO:0048129 |regulation of mitosis ; GO:0007088 |response to external stimulus ; GO:0009605 |response to radiation ; GO:0009314 CEL|chromosome ; GO:0005694 |cytoplasm ; GO:0005737 |nucleus ; GO:0005634 |ring canal (sensu Insecta) ; GO:0045172 PDOM|IPR000308 == 14-3-3 protein GLC|Maps 0.4 +/- 0.2 cM from a P{w+} insertion into 90E. WT|@14-3-3&egr;@ is required to time mitosis in undisturbed post-blastoderm |cell cycles and to delay mitosis following irradiation in embryos. ENZ|transcription regulator activity ; GO:0030528 | inferred from electronic annotation |transcription regulator activity ; GO:0030528 |diacylglycerol-activated phospholipid-dependent protein kinase C inhibitor activity ; GO:0004863 |diacylglycerol-activated phospholipid-dependent protein kinase C inhibitor activity ; GO:0004863 | non-traceable author statement |protein domain specific binding ; GO:0019904 |protein domain specific binding ; GO:0019904 | inferred from electronic annotation DBA|NA:AE003721 |PA:AAF55519 |PA:AAN13764 |PA:AAN13765 |PA:AAN13766 |NA:AQ026302 |BDGP:l(3)j2B10 |NA:AX260179 |NA:AX664478 |NA:CZ470936 |NA:CZ470942 |NA:CZ470943 |NA:CZ478211 |NA:CZ481589 |NA:CZ487692 |NA:CZ487693 |NA:U84897 |PA:AAC47519 |NA:U84898 |PA:AAC47520 PAC|UniProt_Swiss_Prot:P92177 |UniProt_TrEMBL:Q8IN86 ASQ|FBan0031196 REV|FBrf0158832 |FBrf0111327 |FBrf0127283 REF { REFM|FBrf0154848 |1 REFM|FBrf0111489 |Spradling et al. |1999 |0 REFM|FBrf0179731 |Bilder |2004 |2 REFM|FBrf0151902 |Benton et al. |2002 |0 REFM|FBrf0091142 |Perrimon et al. |1996 |0 REFM|FBrf0158832 |Ahringer |2003 |2 REFM|FBrf0173208 |Benton and St. Johnston |2003 |0 REFM|FBrf0179120 |Baas et al. |2004 |2 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 REFM|FBrf0111327 |Baek and Lee |1999 |2 REFM|FBrf0141233 |Deak et al. |2001.10.4 |9 REFM|FBrf0131405 |Therrien et al. |2000 |0 REFM|FBrf0174215 |FlyBase Curators et al. |2004- |9 REFM|FBrf0179660 |Jaramillo et al. |2004 |1 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0179050 |Macara |2004 |2 REFM|FBrf0126669 |Gong |1999.11 |9 REFM|FBrf0126349 |Su |2000 |1 REFM|FBrf0104946 |FlyBase |1996- |9 REFM|FBrf0134532 |Walworth |2000 |2 REFM|FBrf0127357 |Teeter et al. |2000 |0 REFM|FBrf0104620 |Rommel and Hafen |1998 |2 REFM|FBrf0108031 |Tien et al. |1999 |0 REFM|FBrf0067338 |BDGP Project Members |1994-1999 |9 REFM|FBrf0133450 |Acevedo and Skoulakis |2001 |1 REFM|FBrf0083714 |Meister and Braun |1995.10 |9 REFM|FBrf0186800 |Tsigari et al. |2005 |0 REFM|FBrf0145821 |Acevedo and Skoulakis |2002 |1 REFM|FBrf0173511 |Skoulakis et al. |2004 |1 REFM|FBrf0139721 |Su et al. |2001 |0 REFM|FBrf0151887 |Rebay |2002 |2 REFM|FBrf0127283 |Raabe |2000 |2 REFM|FBrf0159706 |Hacker et al. |2003 |0 REFM|FBrf0113722 |Chang |1997.1.11 |9 REFM|FBrf0113721 |Chang |1997.1.10 |9 REFM|FBrf0102393 |Rubin et al. |1997 |2 REFM|FBrf0108153 |Chen and Chien |1999 |0 REFM|FBrf0126913 |Bayraktaroglu |2000.4.13 |9 REFM|FBrf0161459 |Mi et al. |2003.9.9 |9 REFM|FBrf0126651 |Ashburner |1999.11 |9 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0126680 |Lei |1999.11 |9 REFM|FBrf0127025 |Brodsky et al. |2000 |0 REFM|FBrf0149093 |Johannes and Preiss |2002 |0 REFM|FBrf0173982 |Wang and Cooley |2004 |1 REFM|FBrf0124174 |Swiss-Prot Project Members |1998.2.1 |9 REFM|FBrf0145847 |Skoulakis and Acevedo |2002 |1 REFM|FBrf0159690 |Chen et al. |2003 |0 REFM|FBrf0166452 |Giot et al. |2003 |9 REFM|FBrf0133630 |Purdy et al. |2001 |1 REFM|FBrf0087493 |Karim et al. |1996 |0 REFM|FBrf0155512 |Pellettieri and Seydoux |2002 |2 REFM|FBrf0129944 |Li et al. |2000 |0 REFM|FBrf0086382 |Dickson et al. |1996 |0 REFM|FBrf0184340 |Gene Disruption Project members and Exelixis |2005 |9 REFM|FBrf0167337 |de Morais Guedes et al. |2003 |0 REFM|FBrf0179255 |Huynh and St. Johnston |2004 |2 REFM|FBrf0130073 |Sekelsky et al. |2000 |0 REFM|1888132925 |0 |Patent: WO 02059370-A 01-AUG-2002; REFM|FBrf0158996 |Li and Li |2003 |0 REFM|FBrf0093395 |Chang and Rubin |1997 |0 } REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 CLOC|90F6--7 LOI|14-3-3&egr;j2B10 BMD|Df(3R)P14 } REFDSR { RDID|FBrf0086382 |Dickson et al. |1996 GLC|Maps 0.4 +/- 0.2 cM from a P{w+} insertion into 90E. WTI|phl (data from @14-3-3&egr;18A2@) PHP|Identified in a genetic screen for modifiers of the @phl::tor12D.sev@ |rough eye mutant phenotype. } REFDSR { RDID|FBrf0087493 |Karim et al. |1996 GLOC|3- CLOC|90E--F CYC|On basis of meiotic mapping (details unspecified). WTI|Dsor1 (data from @14-3-3&egr;S-1259@, @14-3-3&egr;S-696@) |Ras85D (data from @14-3-3&egr;S-1259@, @14-3-3&egr;S-696@) |aop (data from @14-3-3&egr;S-1259@, @14-3-3&egr;S-696@) |phl (data from @14-3-3&egr;S-1259@, @14-3-3&egr;S-696@) PHP|Identified on the basis of genetic interaction with @Ras85DV12.sev@. SYN|SR3-9 |Suppressor of Ras85D 3-9 } REFDSR { RDID|FBrf0091142 |Perrimon et al. |1996 CLOC|90F6--7 (determined by in situ hybridization) PHP|The autosomal "FLP-DFS" technique (using the @P{ovoD1-18}@ @P{FRT(whs)}@ |@P{hsFLP}@ chromosomes) has been used to identify the specific maternal |effect phenotype for the zygotic lethal mutation. @14-3-3&egr;@ gene |expression during oogenesis is not critical to embryonic development, |but the gene function may be essential for fertilization and/or completion |of meiosis. } REFDSR { RDID|FBrf0093395 |Chang and Rubin |1997 GLOC|3-62.0 WTI|14-3-3&zgr; (data from @14-3-3&egr;j2B10@) |Ras85D (data from @14-3-3&egr;S-1259@, @14-3-3&egr;S-696@, @14-3-3&egr;j2B10@) |phl (data from @14-3-3&egr;18A2@, @14-3-3&egr;S-1259@, @14-3-3&egr;S-696@, @14-3-3&egr;j2B10@) PHP|@14-3-3&egr;@ has been cloned and characterized. Genetic studies suggest |that @14-3-3&egr;@ functions in multiple receptor tyrosine kinase pathways, |acting downstream or parallel to @phl@, but upstream of @aop@ and @phyl@, |two nuclear factors involved in @Ras85D@ signaling. } REFDSR { RDID|FBrf0104620 |Rommel and Hafen |1998 SYN|14-3-3 } REFDSR { RDID|FBrf0104946 |FlyBase |1996- AM|Source for merge of: 14-3-3&egr; anon-WO0172774.141 anon-WO02059370.52 |Source for merge of 14-3-3&egr; anon-WO0172774.141 anon-WO02059370.52 |was sequence comparison (date:051113). } REFDSR { RDID|FBrf0108031 |Tien et al. |1999 BMD|Df(3R)P14 SYN|d14-3-3&egr; } REFDSR { RDID|FBrf0108153 |Chen and Chien |1999 SYN|d14-3-3&egr; } REFDSR { RDID|FBrf0111327 |Baek and Lee |1999 SYN|14-3-3 } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 CLOC|90F6--7 (determined by in situ hybridization) LOI|14-3-3&egr;j2B10 BMD|Df(3R)P14 SYN|14-3-3epsilon } REFDSR { RDID|FBrf0113721 |Chang |1997.1.10 ENZ|diacylglycerol-activated phospholipid-dependent protein kinase C inhibitor activity ; GO:0004863 | non-traceable author statement CLOC|90F6--7 FNC|Ras protein signal transduction ; GO:0007265 | non-traceable author statement GPD|14-3-3-protein SYN|14-3-3e } REFDSR { RDID|FBrf0113722 |Chang |1997.1.11 SYN|14-3-3e } REFDSR { RDID|FBrf0124174 |Swiss-Prot Project Members |1998.2.1 FNC|Ras protein signal transduction ; GO:0007265 | non-traceable author statement } REFDSR { RDID|FBrf0126669 |Gong |1999.11 AM|Source for identity of: 14-3-3&egr; CG8045 } REFDSR { RDID|FBrf0126913 |Bayraktaroglu |2000.4.13 SYN|CT24092 } REFDSR { RDID|FBrf0127025 |Brodsky et al. |2000 FNC|DNA damage checkpoint ; GO:0000077 | inferred from mutant phenotype } REFDSR { RDID|FBrf0127283 |Raabe |2000 SYN|14-3-3 } REFDSR { RDID|FBrf0129944 |Li et al. |2000 WTI|phl (data from @14-3-3&egr;&Dgr;24@) } REFDSR { RDID|FBrf0130073 |Sekelsky et al. |2000 FNC|DNA damage checkpoint ; GO:0000077 | traceable author statement } REFDSR { RDID|FBrf0131405 |Therrien et al. |2000 WTI|ksr |Ras85D (data from @14-3-3&egr;unspecified@) |phl (data from @14-3-3&egr;unspecified@) SYN|EK3-5 } REFDSR { RDID|FBrf0133450 |Acevedo and Skoulakis |2001 SYN|D14-3-3&egr; } REFDSR { RDID|FBrf0134532 |Walworth |2000 FNC|imaginal disc development ; GO:0007444 | traceable author statement |mitotic checkpoint ; GO:0007093 | traceable author statement |response to radiation ; GO:0009314 | traceable author statement SYN|14-3-3e } REFDSR { RDID|FBrf0139721 |Su et al. |2001 FNC|DNA damage checkpoint ; GO:0000077 | inferred from mutant phenotype |regulation of mitosis ; GO:0007088 | inferred from mutant phenotype CEL|chromosome ; GO:0005694 | inferred from direct assay |cytoplasm ; GO:0005737 | inferred from direct assay |nucleus ; GO:0005634 | inferred from direct assay WT|@14-3-3&egr;@ is required to time mitosis in undisturbed post-blastoderm |cell cycles and to delay mitosis following irradiation in embryos. } REFDSR { RDID|FBrf0145821 |Acevedo and Skoulakis |2002 SYN|D14-3-3&egr; } REFDSR { RDID|FBrf0145847 |Skoulakis and Acevedo |2002 FNC|response to external stimulus ; GO:0009605 | inferred from mutant phenotype SYN|D14-3-3&egr; } REFDSR { RDID|FBrf0149093 |Johannes and Preiss |2002 SYN|14-3-3-e } REFDSR { RDID|FBrf0151887 |Rebay |2002 SYN|14-3-3 } REFDSR { RDID|FBrf0151902 |Benton et al. |2002 FNC|maintenance of oocyte identity (sensu Insecta) ; GO:0016350 | inferred from mutant phenotype |oocyte microtubule cytoskeleton polarization (sensu Insecta) ; GO:0048129 | inferred from mutant phenotype CEL|ring canal (sensu Insecta) ; GO:0045172 | inferred from direct assay BMD|Df(3R)P14 WTI|14-3-3&zgr; (data from @14-3-3&egr;S-1259@, @14-3-3&egr;j2B10@) |par-1 (data from @14-3-3&egr;j2B10@) } REFDSR { RDID|FBrf0154848 FNC|nonassociative learning ; GO:0046958 | non-traceable author statement SYN|D14-3-3e } REFDSR { RDID|FBrf0155512 |Pellettieri and Seydoux |2002 SYN|par-5 } REFDSR { RDID|FBrf0158996 |Li and Li |2003 WTI|tor (data from @14-3-3&egr;&Dgr;24@) } REFDSR { RDID|FBrf0159706 |Hacker et al. |2003 SYN|14-3-3 } REFDSR { RDID|FBrf0161459 |Mi et al. |2003.9.9 ENZ|transcription regulator activity ; GO:0030528 | inferred from electronic annotation } REFDSR { RDID|FBrf0166452 |Giot et al. |2003 SYN|14-3-3epsilon } REFDSR { RDID|FBrf0167337 |de Morais Guedes et al. |2003 } REFDSR { RDID|FBrf0173208 |Benton and St. Johnston |2003 WTI|14-3-3&zgr; (data from @14-3-3&egr;j2B10@) } REFDSR { RDID|FBrf0173511 |Skoulakis et al. |2004 SYN|D14-3-3&egr; } REFDSR { RDID|FBrf0174215 |FlyBase Curators et al. |2004- ENZ|protein domain specific binding ; GO:0019904 | inferred from electronic annotation } REFDSR { RDID|FBrf0179050 |Macara |2004 SYN|14-3-3 |Par-5 } REFDSR { RDID|FBrf0179120 |Baas et al. |2004 SYN|PAR5 } REFDSR { RDID|FBrf0179255 |Huynh and St. Johnston |2004 SYN|par-5 |14-3-3 } REFDSR { RDID|FBrf0179660 |Jaramillo et al. |2004 SYN|14-3-3 } REFDSR { RDID|FBrf0179731 |Bilder |2004 SYN|14-3-3 } ALESR { ASYM|14-3-3&egr;&Dgr;24 ID|FBal0122336 REF|FBrf0158996 |FBrf0129944 REFDSR { RDID|FBrf0129944 |Li et al. |2000 GIC2|lethal with @phlSu2@ } REFDSR { RDID|FBrf0158996 |Li and Li |2003 GIA|suppressor | maternal effect of embryonic/first instar larval cuticle | maternal effect phenotype of @tor12D@ } } ALESR { ASYM|14-3-3&egr;18A2 SYN|14-3-3&egr;Y214F |18A2 ID|FBal0049166 REF|FBrf0093395 |FBrf0086382 REFDSR { RDID|FBrf0086382 |Dickson et al. |1996 MU|ethyl methanesulfonate GIC|suppressor | dominant of visible phenotype of @phl::tor12D.sev@ GIA|suppressor | dominant of eye phenotype of @phl::tor12D.sev@ |suppressor | dominant of photoreceptor cell R7 phenotype of @phl::tor12D.sev@ GIC2|lethal | dominant with @phl12@ GII|Dominantly suppresses the rough eye phenotype of |@phl::tor12D.sev@. Synthetic lethal in combination with @phl12@. PHC|viable |female fertile ALC|antimorph PHI|Homozygous viable with no obvious defects in eye development. } REFDSR { RDID|FBrf0093395 |Chang and Rubin |1997 MD|Amino acid replacement: Y214F. MU|ethyl methanesulfonate GIC2|lethal | dominant with @phl12@ PHC|viable |fertile PHI|Homozygotes have no detectable phenotype in a wild-type background. SYN|14-3-3&egr;Y214F |18A2 } } ALESR { ASYM|14-3-3&egr;c06705 ID|FBal0188365 REF|FBrf0184340 REFDSR { RDID|FBrf0184340 |Gene Disruption Project members and Exelixis |2005 TRN|FBti0045941 == PBac{PB}14-3-3&egr;c06705 MU|piggyBac transposase } } ALESR { ASYM|14-3-3&egr;c06714 ID|FBal0188364 REF|FBrf0184340 REFDSR { RDID|FBrf0184340 |Gene Disruption Project members and Exelixis |2005 TRN|FBti0066279 == PBac{PB}14-3-3&egr;c06714 MU|piggyBac transposase } } ALESR { ASYM|14-3-3&egr;e00326 ID|FBal0188363 REF|FBrf0184340 REFDSR { RDID|FBrf0184340 |Gene Disruption Project members and Exelixis |2005 TRN|FBti0046352 == PBac{RB}14-3-3&egr;e00326 MU|piggyBac transposase } } ALESR { ASYM|14-3-3&egr;e03838 ID|FBal0188362 REF|FBrf0184340 REFDSR { RDID|FBrf0184340 |Gene Disruption Project members and Exelixis |2005 TRN|FBti0048514 == PBac{RB}14-3-3&egr;e03838 MU|piggyBac transposase } } ALESR { ASYM|14-3-3&egr;EP3423 ID|FBal0157549 REF|FBrf0104946 REFDSR { RDID|FBrf0104946 |FlyBase |1996- TRN|FBti0011566 == P{EP}14-3-3&egr;EP3423 MU|P-element activity } SK|FBst0102382 |P{EP}14-3-3epsilon[EP3423] |FBst0017126 |w[1118]; P{w[+mC]=EP}14-3-3epsilon[EP3423] } ALESR { ASYM|14-3-3&egr;EP3578 ID|FBal0157548 REF|FBrf0104946 REFDSR { RDID|FBrf0104946 |FlyBase |1996- TRN|FBti0011678 == P{EP}14-3-3&egr;EP3578 MU|P-element activity } SK|FBst0103552 |P{EP}14-3-3epsilon[EP3578] |FBst0017142 |w[1118]; P{w[+mC]=EP}14-3-3epsilon[EP3578]/TM6B, Tb[1] } ALESR { ASYM|14-3-3&egr;ex4 ID|FBal0148514 ALC|loss of function REF|FBrf0159690 REFDSR { RDID|FBrf0159690 |Chen et al. |2003 MD|Imprecise mobilization of the @P{lacW}14-3-3&egr;j2B10@ element has |created this allele. PRG|14-3-3&egr;j2B10 MU|P-element activity ALC|loss of function } } ALESR { ASYM|14-3-3&egr;f05080 ID|FBal0188361 REF|FBrf0184340 REFDSR { RDID|FBrf0184340 |Gene Disruption Project members and Exelixis |2005 TRN|FBti0052173 == PBac{WH}14-3-3&egr;f05080 MU|piggyBac transposase } } ALESR { ASYM|14-3-3&egr;j2B10 SYN|l(3)j2B10 |l(3)2B10 |14-3-3&egr;j2b10 |14-3-3-ej2B10 ID|FBal0010913 TRN|FBti0004920 == P{lacW}14-3-3&egr;j2B10 |BDGP:l(3)j2B10 MU|P-element activity REF|FBrf0067338 |FBrf0173208 |FBrf0151902 |FBrf0127025 |FBrf0093395 |FBrf0108153 |FBrf0159690 |FBrf0149093 |FBrf0083714 |FBrf0091142 |FBrf0111489 |FBrf0139721 REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 OTH|Complements: @repo03702@. |Complements: @l(3)0582205822@. |Complements: @MED17s2956@. TRN|FBti0004920 == P{lacW}14-3-3&egr;j2B10 |BDGP:l(3)j2B10 } REFDSR { RDID|FBrf0091142 |Perrimon et al. |1996 PHC|lethal | larval stage | recessive |lethal | embryonic stage | maternal effect PHM|embryonic cuticle | maternal effect PHI|Germline clones produce normal eggs with no cuticle development. } REFDSR { RDID|FBrf0093395 |Chang and Rubin |1997 AFC|14-3-3&egr;S-696 MD|Insertion of a @P{lacW}@ element within the first intron. OTH|The rough eye and missing photoreceptor cell phenotype of @14-3-3&egr;S-696@/@14-3-3&egr;j2B10@ |flies is reverted by mobilization of the @P-element@ in @14-3-3&egr;j2B10@. |The recessive lethality of the @14-3-3&egr;j2B10@ chromosome is not |associated with the @P-element@ insertion. TRN|FBti0004920 == P{lacW}14-3-3&egr;j2B10 |BDGP:l(3)j2B10 MU|P-element activity GIC|suppressor | recessive of visible phenotype of @Ras85DV12.sev@ GIC2|lethal | recessive with @14-3-3&zgr;P2355@/+ |visible | recessive with @14-3-3&zgr;X1@/+ |visible | recessive with @14-3-3&zgr;2.3@/+ |lethal | dominant with @phl12@ GIA|suppressor | recessive of eye phenotype of @Ras85DV12.sev@ |suppressor | recessive of ommatidium phenotype of @Ras85DV12.sev@ GIA2|ommatidium with @14-3-3&zgr;X1@/+ |ommatidium with @14-3-3&zgr;2.3@/+ |posterior crossvein with @14-3-3&zgr;2.3@ |eye with @14-3-3&zgr;2.3@ |photoreceptor cell with @14-3-3&zgr;2.3@ |posterior crossvein with @14-3-3&zgr;X1@ |eye with @14-3-3&zgr;X1@ |photoreceptor cell with @14-3-3&zgr;X1@ GII|Homozygotes but not heterozygotes suppress the @Ras85DV12.sev@ |rough eye phenotype. |@14-3-3&zgr;X1@/+ @14-3-3&egr;j2B10@/@14-3-3&egr;j2B10@ or |@14-3-3&zgr;2.3@/+ @14-3-3&egr;j2B10@/@14-3-3&egr;j2B10@ flies |have slightly roughened eyes, a low penetrance of missing |photoreceptors and a gap in the posterior crossvein of the wings in |more than 50% of cases. PHC|viable |sterile | recessive |(with 14-3-3&egr;S-696) visible PHM|(with 14-3-3&egr;S-696) eye |(with 14-3-3&egr;S-696) photoreceptor cell |(with 14-3-3&egr;S-696) ommatidium ALC|loss of function PHI|Homozygotes have normal eyes but are sterile. |@14-3-3&egr;S-696@/@14-3-3&egr;j2B10@ flies have rough eyes and |a low penetrance of missing photoreceptors in the ommatidia. SYN|l(3)j2B10 } REFDSR { RDID|FBrf0108153 |Chen and Chien |1999 GIA2|(with Df(3R)P14) photoreceptor cell R8 with @EgfrE1@ GII|R8 photoreceptor cells fail to form in @EgfrE1@/+ ; @14-3-3&egr;j2B10@/@Df(3R)P14@ |eye discs. SYN|l(3)2B10 } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 TRN|FBti0004920 == P{lacW}14-3-3&egr;j2B10 |BDGP:l(3)j2B10 PHC|lethal | recessive SYN|l(3)j2B10 } REFDSR { RDID|FBrf0127025 |Brodsky et al. |2000 PHI|In the absence of irradiation, @14-3-3&egr;j2B10@ animals have a |normal external appearance, normal imaginal disc morphology and normal |numbers of mitotic cells in the discs. After irradiation, the number |of mitotic cells in @14-3-3&egr;j2B10@ discs is greater than the |number found in irradiated wild-type discs. SYN|14-3-3&egr;j2b10 } REFDSR { RDID|FBrf0139721 |Su et al. |2001 TRN|FBti0004920 == P{lacW}14-3-3&egr;j2B10 |BDGP:l(3)j2B10 PHC|mitotic | recessive PHM|cycle 14 embryo PHI|Embryos derived from a cross of @14-3-3&egr;j2B10@/@Df(3R)Cha7@ females |to @14-3-3&egr;j2B10@/@Df(3R)Cha7@ males progress through the first |13 mitotic cycles and cellularize without obvious defects. Cells enter |mitosis 14 prematurely compared to wild type so that the division pattern |of mutant embryos in gastrulation is more advanced than in wild-type |embryos of similar gastrulation but is similar to wild-type embryos |of more advanced gastrulation. The entire schedule of mitosis is advanced |without disrupting the relative order of mitosis in different positions |within the embryo. The rate of germ-band elongation is indistinguishable |from wild type. Mutant embryos do not show a delay of entry into mitosis |14 after irradiation, in contrast to wild-type embryos. SYN|l(3)j2B10 } REFDSR { RDID|FBrf0149093 |Johannes and Preiss |2002 SYN|14-3-3-ej2B10 } REFDSR { RDID|FBrf0151902 |Benton et al. |2002 GIA2|nurse cell | ectopic | germ-line clone, enhanceable by @14-3-3&zgr;P1188@ |oocyte, enhanceable by @par-1W3@/+ |oocyte | germ-line clone with @14-3-3&zgr;P1188@ GIA|enhancer of oocyte phenotype of @par-1W3@ GIA2|oocyte | germ-line clone, enhanceable by @14-3-3&zgr;P1188@ GII|The penetrance of the oocyte to nurse cell transformation phenotype |seen in @14-3-3&egr;j2B10@ germ-line clones (80% n=106) is dominantly |enhanced to 100% by @14-3-3&zgr;P1188@. |In @14-3-3&egr;j2B10@ mutant egg chambers that develop an oocyte, |the penetrance of oocyte polarization defects in oocytes at stage 10 |is dominantly enhanced by @par-1W3@. |Many @14-3-3&zgr;P1188@ germ-line clones in @14-3-3&egr;j2B10@/+ |females have defects in oocyte specification and polarization. PHC|viable |female sterile | recessive |(with Df(3R)P14) viable |(with Df(3R)P14) female sterile PHM|oocyte |nurse cell | ectopic |(with Df(3R)P14) oocyte |(with Df(3R)P14) nurse cell | ectopic |oocyte | germ-line clone |nurse cell | ectopic | germ-line clone |microtubule organizing center |oocyte |oocyte |centrosome |microtubule |oocyte ALC|loss of function PHI|In @14-3-3&egr;j2B10@ homozygotes or @14-3-3&egr;j2B10@/@Df(3R)P14@ |females most egg chambers lack a differentiated oocyte: both of the |nurse cells with four ring canals develop as nurse cells. The same |phenotype is caused by @14-3-3&egr;j2B10@ germ-line clones, but not |@14-3-3&egr;j2B10@ somatic clones in the ovarian follicle cells. |The microtubule organizing center which is visible in the posterior |of the prospective oocyte as early as stage 2 in wild-type, is absent |from @14-3-3&egr;j2B10@ mutants at this stage. The centrosomes do |not undergo the anterior-to-posterior movement and eventually diffuse |away as this cell exits meiosis and adopts a nurse cell fate. In @14-3-3&egr;j2B10@ |mutant egg chambers where oocyte specification does occur, marker analysis |at stage 10 shows a partially penetrant oocyte polarization phenotype, |although migration of the oocyte nucleus occurs normally. These oocytes |also show defects in microtubule organization. } REFDSR { RDID|FBrf0159690 |Chen et al. |2003 TRN|FBti0004920 == P{lacW}14-3-3&egr;j2B10 |BDGP:l(3)j2B10 } REFDSR { RDID|FBrf0173208 |Benton and St. Johnston |2003 GIA2|follicle cell with @14-3-3&zgr;P1188@/@14-3-3&zgr;P1375@ GII|Follicular epithelium morphogenesis is normal in @14-3-3&zgr;P1188@/@14-3-3&zgr;P1375@ |; @14-3-3&egr;j2B10@/+ egg chambers up to stage 4, but the follicle |cells subsequently lose their regular cuboidal shape. } SK|FBst0012142 |y[1] w[*]; P{w[+mC]=lacW}14-3-3epsilon[j2B10]/TM3, Sb[1] } ALESR { ASYM|14-3-3&egr;PL00784 SYN|l(3)PL00784 ID|FBal0148516 PHC|lethal | embryonic stage | maternal effect | germ-line clone PHM|embryo | maternal effect | germ-line clone PHI|@14-3-3&egr;PL00784@ germ-line clones produce embryos that die before |they produce a larval cuticle and appear as 'empty eggs'. REF|FBrf0159706 REFDSR { RDID|FBrf0159706 |Hacker et al. |2003 MD|The @PBac{GAL4D,EYFP}@ insertion is in the first |intron of @14-3-3&egr;@. TRN|FBti0038117 == PBac{GAL4D,EYFP}14-3-3&egr;PL00784 MU|piggyBac transposase PHC|lethal | embryonic stage | maternal effect | germ-line clone PHM|embryo | maternal effect | germ-line clone PHI|@14-3-3&egr;PL00784@ germ-line clones produce embryos that die before |they produce a larval cuticle and appear as 'empty eggs'. SYN|l(3)PL00784 } } ALESR { ASYM|14-3-3&egr;S-696 SYN|14-3-3&egr;E183K |SR3-9696 ID|FBal0048994 REF|FBrf0151902 |FBrf0093395 |FBrf0087493 |FBrf0131405 REFDSR { RDID|FBrf0087493 |Karim et al. |1996 MU|ethyl methanesulfonate GIC|suppressor of visible phenotype of @Ras85DV12.sev@ |suppressor of @phl::tor13D.hs.sev@ |suppressor of @Ras85D::Src64BV12.&Dgr;CAAX.sev@ |enhancer of @Ras85DN17.sev@ |enhancer of lethal phenotype of @phl12@ |enhancer of visible phenotype of @phl12@ |enhancer of visible phenotype of @Dsor1XS520@ |enhancer of visible phenotype of @aopS2382@ GIA|suppressor of eye phenotype of @Ras85DV12.sev@ |enhancer of eye phenotype of @phl12@ |enhancer of eye phenotype of @Dsor1XS520@ |enhancer of eye phenotype of @aopS2382@ GII|Suppresses the rough eye phenotype of @Ras85DV12.sev@. PHC|viable | poor PHI|Homozygotes are subviable. } REFDSR { RDID|FBrf0093395 |Chang and Rubin |1997 AFC|14-3-3&egr;j2B10 MD|Amino acid replacement: E183K. MU|ethyl methanesulfonate GIC|suppressor | dominant of @Ras85DV12.sev@ GIC2|lethal | dominant with @phl12@ GIC|suppressor | dominant of @phl::tor13D.hs.sev@ GII|@14-3-3&egr;S-696@ does not show any dominant interaction with @aopyan-1@ |or @phylhs.sev@. PHC|lethal | recessive | partially |(with 14-3-3&egr;j2B10) visible PHM|(with Df(3R)P14) ommatidium |(with 14-3-3&egr;j2B10) eye |(with 14-3-3&egr;j2B10) photoreceptor cell |(with 14-3-3&egr;j2B10) ommatidium |ommatidium |photoreceptor cell |posterior crossvein PHI|62.5% of ommatidia are normal in homozygous escapers, with the remaining |ommatidia lacking some photoreceptor cells, and 69.1% of ommatidia |are normal in @14-3-3&egr;S-696@/@Df(3R)P14@ flies. Homozygous escapers |often have gaps in the posterior crossveins of the wings. |@14-3-3&egr;S-696@/@14-3-3&egr;j2B10@ flies have rough eyes and |a low penetrance of missing photoreceptors in the ommatidia. SYN|14-3-3&egr;E183K |SR3-9696 } REFDSR { RDID|FBrf0151902 |Benton et al. |2002 PHM|oocyte ALC|antimorph PHI|@14-3-3&egr;S-696@ mutant females have oocyte determintaion and polarity |defects with a much higher penetrance than @14-3-3&egr;j2B10@, suggesting |that this allele is antimorphic (dominant negative). SYN|14-3-3&egr;E183K } SK|FBst0006565 |14-3-3epsilon[S-696]/TM3, P{ry[+t7.2]=sevRas1.V12}FK2, Sb[1] } ALESR { ASYM|14-3-3&egr;S-1259 SYN|14-3-3&egr;F199Y |SR3-91259 ID|FBal0048993 REF|FBrf0151902 |FBrf0093395 |FBrf0087493 REFDSR { RDID|FBrf0087493 |Karim et al. |1996 MU|ethyl methanesulfonate GIC|suppressor of visible phenotype of @Ras85DV12.sev@ |suppressor of @phl::tor13D.hs.sev@ |suppressor of @Ras85D::Src64BV12.&Dgr;CAAX.sev@ |enhancer of lethal phenotype of @phl12@ |enhancer of visible phenotype of @phl12@ |enhancer of @Ras85DN17.sev@ |enhancer of visible phenotype of @Dsor1XS520@ |enhancer of visible phenotype of @aopS2382@ |suppressor | dominant of @Ras85DV12.sev@ GIA|suppressor of eye phenotype of @Ras85DV12.sev@ |enhancer of eye phenotype of @phl12@ |enhancer of eye phenotype of @Dsor1XS520@ |enhancer of eye phenotype of @aopS2382@ GII|Suppresses the rough eye phenotype of @Ras85DV12.sev@. PHC|viable | poor PHI|Homozygotes are subviable. } REFDSR { RDID|FBrf0093395 |Chang and Rubin |1997 MD|Amino acid replacement: F199Y. MU|ethyl methanesulfonate GIC|suppressor | dominant of @Ras85DV12.sev@ GIC2|lethal | dominant with @phl12@ PHC|viable |fertile PHI|Homozygotes have no detectable phenotype in a wild-type background. SYN|14-3-3&egr;F199Y |SR3-91259 } REFDSR { RDID|FBrf0151902 |Benton et al. |2002 GIA2|oocyte | germ-line clone with @14-3-3&zgr;P1188@ GII|Many @14-3-3&zgr;P1188@ germ-line clones in @14-3-3&egr;S-1259@/+ |females have defects in oocyte specification. SYN|14-3-3&egr;F199Y } } ALESR { ASYM|14-3-3&egr;Scer\UAS.cCa ID|FBal0148515 PHI|When @14-3-3&egr;Scer\UAS.cCa@ is driven by @Scer\GAL4GMR.PF@ no |deleterious effects are seen. REF|FBrf0159690 REFDSR { RDID|FBrf0159690 |Chen et al. |2003 NAM|Saccharomyces cerevisiae UAS construct a of Chen MD|@Scer\UAS@ sequences drive expression of @14-3-3&egr;@. CNS|FBtp0017453 == P{UAS-14-3-3&egr;.C} GIC2|lethal with @Hsap\ATX182Q.Scer\UAS@ |lethal with @Hsap\ATX182Q.Scer\UAS@, @Scer\GAL4GMR.PF@ |lethal with @Hsap\ATX182Q.Scer\UAS@ |lethal with @Hsap\ATX182Q.Scer\UAS@, @Scer\GAL4GMR.PF@ GIA|enhancer of eye phenotype of @Hsap\ATX182Q.Scer\UAS@, @Scer\GAL4GMR.PF@ |enhancer of retina phenotype of @Hsap\ATX182Q.Scer\UAS@, @Scer\GAL4GMR.PF@ |enhancer of rhabdomere phenotype of @Hsap\ATX182Q.Scer\UAS@, @Scer\GAL4GMR.PF@ PHI|When @14-3-3&egr;Scer\UAS.cCa@ is driven by @Scer\GAL4GMR.PF@ no |deleterious effects are seen. } } ALESR { ASYM|14-3-3&egr;unspecified ID|FBal0121020 PHC|lethal | recessive REF|FBrf0131405 REFDSR { RDID|FBrf0131405 |Therrien et al. |2000 GIA|enhancer | dominant of eye phenotype of @ksr::tor&Dgr;Nksr.hs.sev@ |suppressor | dominant of eye phenotype of @Ras85DV12.sev@ GIC|enhancer | dominant of lethal phenotype of @phl12@ |enhancer | dominant of visible phenotype of @ksr::tor&Dgr;Nksr.hs.sev@ |suppressor | dominant of visible phenotype of @Ras85DV12.sev@ PHC|lethal | recessive } } ALESR { ASYM|14-3-3&egr;+ ID|FBal0079281 CLA|wild-type generic REF|FBrf0105495 } SK|FBst0006565 |14-3-3epsilon[S-696]/TM3, P{ry[+t7.2]=sevRas1.V12}FK2, Sb[1] |FBst0102382 |P{EP}14-3-3epsilon[EP3423] |FBst0103552 |P{EP}14-3-3epsilon[EP3578] |FBst0017126 |w[1118]; P{w[+mC]=EP}14-3-3epsilon[EP3423] |FBst0017142 |w[1118]; P{w[+mC]=EP}14-3-3epsilon[EP3578]/TM6B, Tb[1] |FBst0012142 |y[1] w[*]; P{w[+mC]=lacW}14-3-3epsilon[j2B10]/TM3, Sb[1] SKC|6 } # EOR GENR { RETE|ID 1 FBgn0004907 CLA 1 Gene NAM 1 14-3-3&zgr; GSYM 1 14-3-3&zgr; DT 1 25 Nov 05 RESZ 72747 PDOM 1 INTERPRO:IPR000308 == 14-3-3 protein PTD 1 DBA 42 FNC 11 Ras protein signal transduction CEL 2 nucleus CLOC 1 46E6--8 ALESR 31 SK 2 REF 105 GSYM|14-3-3&zgr; PTD ARGS DT|25 Nov 05 ID|FBgn0004907 UAB|Deficiency: Df(2R)stan1 (inferred from cytology) |Duplication: Dp(2;2)Y3b (inferred from cytology) SYN|CG17870 |CG17870 |549 |2G1 |5.11 |leonardo |leo: leonardo |D14-3-3&zgr; |K |Complementation group K |14-3-3 |14-3-3zeta |Leonardo-13-3-3 |leonardo 14-3-3 |4-3-3 zeta |par-5 |Par-5 |PAR5 |d14-3-3zeta |l(2)46CFe |l(2)46Ee |D14-3-3: D14 3 3 protein |l(2)07103 |BEST:GH05075 |D14 3 3 protein |leo ID2|FBgn0010635 |FBgn0019723 |FBgn0023038 |FBgn0046306 |FBgn0064146 NAM|14-3-3&zgr; CLOC|46E6--8 |Limits computationally determined from genome sequence between @P{lacW}Adamk13906@&@P{EP}Pka-R2EP2162@ and @P{PZ}14-3-3&zgr;07103@ CYC|Experimentally determined: 46C8--F6, 46E, 46E--F, 46E4--8 FNC|Ras protein signal transduction ; GO:0007265 |cell proliferation ; GO:0008283 |chromosome segregation ; GO:0007059 |learning and/or memory ; GO:0007611 |maintenance of oocyte identity (sensu Insecta) ; GO:0016350 |mitotic cell cycle, embryonic ; GO:0045448 |olfactory learning ; GO:0008355 |oocyte microtubule cytoskeleton polarization (sensu Insecta) ; GO:0048129 |photoreceptor cell differentiation (sensu Endopterygota) ; GO:0007467 |regulation of progression through cell cycle ; GO:0000074 |tryptophan hydroxylase activation ; GO:0006588 CEL|nucleus ; GO:0005634 |ring canal (sensu Insecta) ; GO:0045172 PDOM|IPR000308 == 14-3-3 protein ENZ|protein kinase C inhibitor activity ; GO:0008426 | non-traceable author statement |transcription regulator activity ; GO:0030528 | inferred from electronic annotation |transcription regulator activity ; GO:0030528 |protein binding ; GO:0005515 |protein binding ; GO:0005515 | inferred from physical interaction with FLYBASE:Slob; FB:FBgn0024290 |diacylglycerol-activated phospholipid-dependent protein kinase C inhibitor activity ; GO:0004863 |protein kinase C inhibitor activity ; GO:0008426 |tryptophan hydroxylase activator activity ; GO:0016483 |diacylglycerol-activated phospholipid-dependent protein kinase C inhibitor activity ; GO:0004863 | inferred from sequence similarity with UniProt:P35215 |tryptophan hydroxylase activator activity ; GO:0016483 | inferred from sequence similarity with UniProt:P35215 |protein domain specific binding ; GO:0019904 |protein domain specific binding ; GO:0019904 | inferred from electronic annotation DBA|NA:AA538817 |BDGP-DGC:LD18434 |NA:AC005469 |BDGP:DS05181 |NA:AC005974 |BDGP:DS05181 |NA:AE003831 |PA:AAM71060 |PA:AAM71061 |PA:AAF58843 |PA:AAM71062 |PA:AAF58842 |PA:AAS64884 |PA:AAM71063 |PA:AAM71064 |NA:AI064611 |BDGP:GH05075.3prime |NA:AQ025662 |BDGP:l(2)07103 |NA:AW942482 |BDGP-DGC:LD18434 |NA:AY095521 |PA:AAM12253 |BDGP-DGC:LD18434 |NA:BH840513 |BDGP:KG02642 |NA:BI564632 |BDGP-DGC:RH61958 |NA:BI629143 |BDGP-DGC:RH57960 |NA:BT001855 |PA:AAN71617 |BDGP-DGC:RH61958 |NA:CC060506 |NA:CL632153 |NA:M77518 |PA:AAA28324 |NA:Y12573 |PA:CAA73153 |PA:CAA73152 |NA:Z32177 |dbSTS:4728 PAC|UniProt_Swiss_Prot:P29310 |UniProt_TrEMBL:Q8SWR6 ASQ|FBan0017870 REV|FBrf0158832 |FBrf0127283 |FBrf0137068 REF { REFM|FBrf0093395 |Chang and Rubin |1997 |0 REFM|FBrf0159690 |Chen et al. |2003 |0 REFM|FBrf0173208 |Benton and St. Johnston |2003 |0 REFM|FBrf0102616 |Connolly and Tully |1998 |2 REFM|FBrf0101184 |Hermon et al. |1998 |1 REFM|FBrf0178762 |Rana |2004.7.8 |9 REFM|FBrf0084992 |Edwards and Wasserman |1996 |1 REFM|FBrf0102121 |Broadie |1998 |2 REFM|FBrf0101416 |Amanai et al. |1998 |1 REFM|FBrf0056086 |Swanson and Ganguly |1992 |0 REFM|FBrf0057515 |Ganguly et al. |1992 |0 REFM|FBrf0179171 |Collier et al. |2004 |0 REFM|FBrf0179660 |Jaramillo et al. |2004 |1 REFM|FBrf0173651 |Grammenoudi et al. |2004 |1 REFM|FBrf0126651 |Ashburner |1999.11 |9 REFM|FBrf0151902 |Benton et al. |2002 |0 REFM|FBrf0145821 |Acevedo and Skoulakis |2002 |1 REFM|FBrf0099136 |Broadie et al. |1997 |1 REFM|FBrf0133630 |Purdy et al. |2001 |1 REFM|FBrf0145131 |Goldstein et al. |2001 |0 REFM|FBrf0096484 |Tully et al. |1996 |2 REFM|FBrf0155512 |Pellettieri and Seydoux |2002 |2 REFM|FBrf0134535 |Zars |2000 |2 REFM|FBrf0183635 |Wu et al. |2005 |1 REFM|FBrf0147137 |Brody et al. |2002 |0 REFM|FBrf0099525 |Skoulakis et al. |1997 |1 REFM|FBrf0090801 |Skoulakis and Davis |1996 |0 REFM|FBrf0129944 |Li et al. |2000 |0 REFM|FBrf0161459 |Mi et al. |2003.9.9 |9 REFM|FBrf0058506 |McConnell and Hodges |1993 |9 REFM|FBrf0159674 |Whitfield et al. |2002 |9 REFM|FBrf0108310 |Zhou et al. |1999 |0 REFM|FBrf0139731 |Philip et al. |2001 |0 REFM|FBrf0159020 |Zhou et al. |2003 |0 REFM|FBrf0055263 |Swanson and Ganguly |1992 |1 REFM|FBrf0178744 |Goldstein |2004.3.15 |9 REFM|FBrf0083714 |Meister and Braun |1995.10 |9 REFM|FBrf0179255 |Huynh and St. Johnston |2004 |2 REFM|FBrf0125895 |Tallman et al. |2000 |1 REFM|FBrf0137492 |Oliver |2001.8.16 |9 REFM|FBrf0141765 |Waddell and Quinn |2001 |2 REFM|FBrf0100355 |Grotewiel et al. |1998 |0 REFM|FBrf0166452 |Giot et al. |2003 |9 REFM|FBrf0141665 |Sokolowski |2001 |2 REFM|FBrf0179050 |Macara |2004 |2 REFM|FBrf0139721 |Su et al. |2001 |0 REFM|FBrf0104946 |FlyBase |1996- |9 REFM|FBrf0093851 |Mlodzik |1997.5.10 |9 REFM|FBrf0037869 |Levy and Manning |1982 |0 REFM|FBrf0110590 |Prokop |1999 |2 REFM|FBrf0037868 |Levy et al. |1982 |0 REFM|FBrf0179048 |Luschnig et al. |2004 |9 REFM|FBrf0092060 |Amanai et al. |1997 |1 REFM|FBrf0123915 |Swiss-Prot Project Members |1992.12.1 |9 REFM|FBrf0089671 |Han et al. |1996 |0 REFM|FBrf0067338 |BDGP Project Members |1994-1999 |9 REFM|FBrf0098203 |Broadie et al. |1997 |0 REFM|FBrf0132177 |Gene Disruption Project members |2001- |9 REFM|FBrf0130073 |Sekelsky et al. |2000 |0 REFM|FBrf0101895 |Dubnau and Tully |1998 |2 REFM|FBrf0126031 |Johnson Hamlet and Perkins |2000 |1 REFM|FBrf0099365 |Li et al. |1997 |0 REFM|FBrf0099854 |Belvin and Yin |1997 |2 REFM|FBrf0098753 |Carney et al. |1997 |0 REFM|FBrf0151992 |Jauch et al. |2002 |0 REFM|FBrf0107641 |Casci et al. |1999 |0 REFM|FBrf0052826 |Hyde et al. |1990 |0 REFM|FBrf0085952 |Skoulakis and Davis |1996 |1 REFM|FBrf0085951 |Skoulakis and Davis |1996 |1 REFM|FBrf0111489 |Spradling et al. |1999 |0 REFM|FBrf0093549 |Kockel et al. |1997 |0 REFM|FBrf0079774 |Skoulakis |1995 |9 REFM|FBrf0158743 |Sathyanarayana et al. |2003 |0 REFM|FBrf0111327 |Baek and Lee |1999 |2 REFM|FBrf0167437 |Brembs |2003 |2 REFM|FBrf0084657 |Amanai and Shearn |1996 |1 REFM|FBrf0050680 |Palazzolo et al. |1989 |0 REFM|FBrf0079419 |Skoulakis and Davis |1995 |1 REFM|FBrf0127283 |Raabe |2000 |2 REFM|FBrf0076706 |Currie and Sullivan |1994 |0 REFM|FBrf0092345 |Li et al. |1997 |1 REFM|FBrf0167337 |de Morais Guedes et al. |2003 |0 REFM|FBrf0137171 |Roman and Davis |2001 |2 REFM|FBrf0099843 |Isaksson et al. |1997 |0 REFM|FBrf0101626 |Skoulakis |1998 |1 REFM|FBrf0158996 |Li and Li |2003 |0 REFM|FBrf0187664 |Zhu et al. |2005 |0 REFM|FBrf0092792 |Goldstein et al. |1993 |1 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0107534 |Zhang et al. |1999 |0 REFM|FBrf0158832 |Ahringer |2003 |2 REFM|FBrf0174215 |FlyBase Curators et al. |2004- |9 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 REFM|FBrf0103626 |Amanai et al. |1998 |1 REFM|FBrf0133552 |Skoulakis and Philip |2001 |1 REFM|FBrf0179120 |Baas et al. |2004 |2 REFM|FBrf0174700 |Janody et al. |2004 |0 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0133450 |Acevedo and Skoulakis |2001 |1 REFM|FBrf0098932 |Anonymous |1997 |2 REFM|FBrf0104620 |Rommel and Hafen |1998 |2 REFM|FBrf0160472 |Davis et al. |2003 |0 REFM|FBrf0137068 |Davis |2001 |2 REFM|FBrf0144737 |Morley and Montgomery |2001 |2 REFM|FBrf0095439 |Kockel et al. |1997 |0 } REFDSR { RDID|FBrf0037868 |Levy et al. |1982 CLOC|46E (determined by in situ hybridization) PHP|Identified as a cDNA clone that is expressed at a low frequency in |the body but abundantly in the head of the adult. SYN|549 } REFDSR { RDID|FBrf0037869 |Levy and Manning |1982 PHP|Developmental expression pattern of the cDNA clone is examined. SYN|549 } REFDSR { RDID|FBrf0050680 |Palazzolo et al. |1989 PHP|Identified as a cDNA clone that is expressed exclusively or predominantly |in the adult visual system. SYN|unnamed } REFDSR { RDID|FBrf0052826 |Hyde et al. |1990 CLOC|46E (determined by in situ hybridization) PHP|Identified as a cDNA clone that is expressed exclusively or predominantly |in the adult visual system. SYN|2G1 |549 } REFDSR { RDID|FBrf0056086 |Swanson and Ganguly |1992 CLOC|46E (determined by in situ hybridization) PHP|D14-3-3 has been characterized: gene expression is developmentally |regulated and predominantly expressed in the neural tissues of the |fly. } REFDSR { RDID|FBrf0057515 |Ganguly et al. |1992 SYN|549 } REFDSR { RDID|FBrf0058506 |McConnell and Hodges |1993 PHP|The alternate 5' end of @Egfr@ reported by Schejter et al. (Cell 46: |1091--1101) is a cloning artefact and is actually from D14-3-3 of Swanson |and Ganguly (Gene 113: 183--190). } REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 CLOC|46E4--8 LOI|14-3-3&zgr;07103 MD|Identified with: D1325 BMD|Df(2R)X1 BMDD|Df(2R)12 BMDD|Df(2R)X3 } REFDSR { RDID|FBrf0076706 |Currie and Sullivan |1994 SYN|5.11 } REFDSR { RDID|FBrf0079774 |Skoulakis |1995 CLOC|46E--F (determined by in situ hybridization) } REFDSR { RDID|FBrf0085951 |Skoulakis and Davis |1996 SYN|leonardo } REFDSR { RDID|FBrf0085952 |Skoulakis and Davis |1996 SYN|leonardo } REFDSR { RDID|FBrf0089671 |Han et al. |1996 SYN|unnamed } REFDSR { RDID|FBrf0090801 |Skoulakis and Davis |1996 CLOC|46E (determined by in situ hybridization) LOI|14-3-3&zgr;P1.3H |14-3-3&zgr;P1188 |14-3-3&zgr;P1375 PHP|@14-3-3&zgr;@ has a biological role in mushroom body-mediated learning and |memory processes. } REFDSR { RDID|FBrf0092060 |Amanai et al. |1997 SYN|leo } REFDSR { RDID|FBrf0092792 |Goldstein et al. |1993 CLOC|46C8--F6 CYC|Complementation data from unspecified deficiency chromosomes. OTH|Complementation group identified in an EMS and DEB screen to isolate |deficiencies that uncover @Jra@. SYN|unnamed } REFDSR { RDID|FBrf0093395 |Chang and Rubin |1997 WTI|14-3-3&egr; (data from @14-3-3&zgr;2.3@, @14-3-3&zgr;P2355@, @14-3-3&zgr;X1@) SYN|leo } REFDSR { RDID|FBrf0093549 |Kockel et al. |1997 PHP|Genetic studies indicate that @14-3-3&zgr;@ acts downstream of @Ras85D@ |and upstream of @phl@ in the developing eye disc. SYN|D14-3-3&zgr; } REFDSR { RDID|FBrf0095439 |Kockel et al. |1997 BMD|Df(2R)E73 } REFDSR { RDID|FBrf0098203 |Broadie et al. |1997 WT|@14-3-3&zgr;@ may function in the activity-dependent regulation of synaptic |vesicle dynamics to control the pool of releaseable transmitter vesicles |at presynaptic fusion sites. OTH|@14-3-3&zgr;@ is strongly and specifically expressed in the presynaptic |boutons of the neuro muscular junction. PHP|In mutants the basic processes of synaptogenesis and excitation-secretion |coupling are not perturbed, but properties of synaptic modulation such |as transmission augmentation, high frequency transmission fidelity |and post-tetanic potentiation (PTP) are strongly impaired. SYN|leo } REFDSR { RDID|FBrf0098753 |Carney et al. |1997 BMD|Df(2R)X1 BMDD|Df(2R)12 BMDD|Df(2R)X3 SYN|K |Complementation group K } REFDSR { RDID|FBrf0099136 |Broadie et al. |1997 SYN|leonardo } REFDSR { RDID|FBrf0099365 |Li et al. |1997 WTI|faf |tor (data from @14-3-3&zgr;hs.PL@) SYN|leo } REFDSR { RDID|FBrf0099525 |Skoulakis et al. |1997 SYN|leo } REFDSR { RDID|FBrf0099843 |Isaksson et al. |1997 WTI|faf (data from @14-3-3&zgr;E16@) } REFDSR { RDID|FBrf0101184 |Hermon et al. |1998 SYN|14-3-3 } REFDSR { RDID|FBrf0101416 |Amanai et al. |1998 SYN|leo } REFDSR { RDID|FBrf0101626 |Skoulakis |1998 SYN|14-3-3 |leonardo } REFDSR { RDID|FBrf0102121 |Broadie |1998 SYN|leo } REFDSR { RDID|FBrf0102616 |Connolly and Tully |1998 SYN|14-3-3 } REFDSR { RDID|FBrf0104620 |Rommel and Hafen |1998 SYN|14-3-3 } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|diacylglycerol-activated phospholipid-dependent protein kinase C inhibitor activity ; GO:0004863 | inferred from sequence similarity with UniProt:P35215 |tryptophan hydroxylase activator activity ; GO:0016483 | inferred from sequence similarity with UniProt:P35215 FNC|Ras protein signal transduction ; GO:0007265 | inferred from sequence similarity with SGD_LOCUS:BMH2; SGD:S0002506 |tryptophan hydroxylase activation ; GO:0006588 | inferred from sequence similarity with UniProt:P35215 MD|Maps to clone: DS05181 GPD|14-3-3-protein } REFDSR { RDID|FBrf0107534 |Zhang et al. |1999 WTI|Src42A (data from @14-3-3&zgr;07103@) SYN|14-3-3 } REFDSR { RDID|FBrf0107641 |Casci et al. |1999 SYN|leo } REFDSR { RDID|FBrf0108310 |Zhou et al. |1999 ENZ|protein binding ; GO:0005515 | inferred from physical interaction with FLYBASE:Slob; FB:FBgn0024290 MD|@14-3-3&zgr;@ can interact with and modulate @slo@ via @Slob@. The |binding between @14-3-3&zgr;@ and @Slob@ is regulated by calcium/calmodulin-dependent |kinase II phosphorylation. } REFDSR { RDID|FBrf0110590 |Prokop |1999 SYN|leo } REFDSR { RDID|FBrf0111327 |Baek and Lee |1999 SYN|14-3-3 } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 CLOC|46E4--8 (determined by in situ hybridization) LOI|14-3-3&zgr;07103 BMD|Df(2R)X1 BMDD|Df(2R)12 BMDD|Df(2R)X3 SYN|14-3-3zeta } REFDSR { RDID|FBrf0123915 |Swiss-Prot Project Members |1992.12.1 FNC|Ras protein signal transduction ; GO:0007265 | non-traceable author statement |cell proliferation ; GO:0008283 | non-traceable author statement |photoreceptor cell differentiation (sensu Endopterygota) ; GO:0007467 | non-traceable author statement } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: LD18434 (BDGP-DGC) |Identified with: RH61958 (BDGP-DGC) |Identified with: RH57960 (BDGP-DGC) } REFDSR { RDID|FBrf0125895 |Tallman et al. |2000 MD|Gene order: Overall orientation not stated: Pfk? 14-3-3&zgr;? SYN|14-3-3 } REFDSR { RDID|FBrf0126031 |Johnson Hamlet and Perkins |2000 SYN|leonardo } REFDSR { RDID|FBrf0127283 |Raabe |2000 SYN|14-3-3 } REFDSR { RDID|FBrf0129944 |Li et al. |2000 SYN|leo } REFDSR { RDID|FBrf0133450 |Acevedo and Skoulakis |2001 SYN|D14-3-3&zgr; |leo } REFDSR { RDID|FBrf0133552 |Skoulakis and Philip |2001 SYN|leo } REFDSR { RDID|FBrf0134535 |Zars |2000 SYN|Leonardo-13-3-3 } REFDSR { RDID|FBrf0137068 |Davis |2001 SYN|leo } REFDSR { RDID|FBrf0137171 |Roman and Davis |2001 FNC|olfactory learning ; GO:0008355 | non-traceable author statement SYN|leo } REFDSR { RDID|FBrf0137492 |Oliver |2001.8.16 MD|Identified with: GH05075.3prime } REFDSR { RDID|FBrf0139721 |Su et al. |2001 FNC|chromosome segregation ; GO:0007059 | inferred from mutant phenotype |mitotic cell cycle, embryonic ; GO:0045448 | inferred from mutant phenotype CEL|nucleus ; GO:0005634 | non-traceable author statement WT|@14-3-3&zgr;@ is required for normal chromosome separation during syncytial |mitoses in the embryo. } REFDSR { RDID|FBrf0139731 |Philip et al. |2001 FNC|learning and/or memory ; GO:0007611 | inferred from mutant phenotype WT|Both isoforms of the @14-3-3&zgr;@ gene are required acutely (as opposed |to developmentally) for normal learning and memory. SYN|leo } REFDSR { RDID|FBrf0141665 |Sokolowski |2001 ENZ|protein kinase C inhibitor activity ; GO:0008426 | non-traceable author statement FNC|learning and/or memory ; GO:0007611 | non-traceable author statement } REFDSR { RDID|FBrf0141765 |Waddell and Quinn |2001 SYN|leo |leonardo } REFDSR { RDID|FBrf0144737 |Morley and Montgomery |2001 SYN|14-3-3 |leonardo } REFDSR { RDID|FBrf0145131 |Goldstein et al. |2001 AM|Source for merge of: 14-3-3&zgr; l(2)46Ee BMD|Df(2R)X1 BMDD|Ab(2R)55-20 BMDD|Ab(2R)89-22 BMDD|Df(2R)520 BMDD|Df(2R)61-25 BMDD|Df(2R)64-10 BMDD|Df(2R)71-81 BMDD|Df(2R)X3 BMDD|Df(2R)eve BMDD|Df(2R)stan2 SYN|Complementation group K |leonardo 14-3-3 } REFDSR { RDID|FBrf0145821 |Acevedo and Skoulakis |2002 SYN|leonardo } REFDSR { RDID|FBrf0147137 |Brody et al. |2002 SYN|4-3-3 zeta } REFDSR { RDID|FBrf0151902 |Benton et al. |2002 FNC|maintenance of oocyte identity (sensu Insecta) ; GO:0016350 | inferred from genetic interaction with FLYBASE:14-3-3&egr;; FB:FBgn0020238 |oocyte microtubule cytoskeleton polarization (sensu Insecta) ; GO:0048129 | inferred from genetic interaction with FLYBASE:14-3-3&egr;; FB:FBgn0020238 CEL|ring canal (sensu Insecta) ; GO:0045172 | inferred from direct assay WTI|14-3-3&egr; (data from @14-3-3&zgr;P1188@) SYN|leo } REFDSR { RDID|FBrf0151992 |Jauch et al. |2002 SYN|leo } REFDSR { RDID|FBrf0155512 |Pellettieri and Seydoux |2002 SYN|par-5 } REFDSR { RDID|FBrf0158743 |Sathyanarayana et al. |2003 SYN|leo } REFDSR { RDID|FBrf0158832 |Ahringer |2003 SYN|leo } REFDSR { RDID|FBrf0158996 |Li and Li |2003 WTI|tor (data from @14-3-3&zgr;P1188@) SYN|leo } REFDSR { RDID|FBrf0159690 |Chen et al. |2003 SYN|leo } REFDSR { RDID|FBrf0160472 |Davis et al. |2003 SYN|leonardo } REFDSR { RDID|FBrf0161459 |Mi et al. |2003.9.9 ENZ|transcription regulator activity ; GO:0030528 | inferred from electronic annotation FNC|regulation of progression through cell cycle ; GO:0000074 | inferred from electronic annotation } REFDSR { RDID|FBrf0166452 |Giot et al. |2003 SYN|14-3-3zeta } REFDSR { RDID|FBrf0167337 |de Morais Guedes et al. |2003 SYN|CG17870 } REFDSR { RDID|FBrf0167437 |Brembs |2003 SYN|leonardo } REFDSR { RDID|FBrf0173208 |Benton and St. Johnston |2003 WTI|14-3-3&egr; (data from @14-3-3&zgr;P1188@, @14-3-3&zgr;P1375@) SYN|leo } REFDSR { RDID|FBrf0174215 |FlyBase Curators et al. |2004- ENZ|protein domain specific binding ; GO:0019904 | inferred from electronic annotation } REFDSR { RDID|FBrf0174700 |Janody et al. |2004 SYN|leonardo } REFDSR { RDID|FBrf0178744 |Goldstein |2004.3.15 AM|Source for merge of: 14-3-3&zgr; l(2)46CFe } REFDSR { RDID|FBrf0178762 |Rana |2004.7.8 AM|Source for merge of: 14-3-3&zgr; BEST:GH05075 } REFDSR { RDID|FBrf0179048 |Luschnig et al. |2004 SYN|leo } REFDSR { RDID|FBrf0179050 |Macara |2004 SYN|14-3-3 |Par-5 } REFDSR { RDID|FBrf0179120 |Baas et al. |2004 SYN|PAR5 } REFDSR { RDID|FBrf0179171 |Collier et al. |2004 SYN|14-3-3 } REFDSR { RDID|FBrf0179255 |Huynh and St. Johnston |2004 SYN|par-5 |14-3-3 } REFDSR { RDID|FBrf0179660 |Jaramillo et al. |2004 SYN|14-3-3 } REFDSR { RDID|FBrf0183635 |Wu et al. |2005 SYN|d14-3-3zeta } ALESR { ASYM|14-3-3&zgr;07103 SYN|l(2)-07103 |l(2)K07103 |l(2)k07103 |l(2)07103 |leo07103 |14-3-3&zgr;P07103 |14-3-307103 |l(2)0710307103 ID|FBal0008125 DBA|NA:Y12573 DIS|A. Spradling. TRN|FBti0009122 == P{PZ}14-3-3&zgr;07103 |BDGP:l(2)07103 MU|P-element activity REF|FBrf0067338 |FBrf0159690 |FBrf0145131 |FBrf0095439 |FBrf0093549 |FBrf0083714 |FBrf0093851 |FBrf0111489 |FBrf0107534 |FBrf0187664 REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 OTH|Complements: @CCS03221@. |Complements: @TER9403775@. |Complements: @Pfk06339@. |Complements: @l(2)k03610k03610@. |Complements: @l(2)k03610k03703@. |Complements: @l(2)k04308k04308@. |Complements: @l(2)46Edk16104@. TRN|FBti0009122 == P{PZ}14-3-3&zgr;07103 |BDGP:l(2)07103 } REFDSR { RDID|FBrf0093549 |Kockel et al. |1997 AMSO|The lethality is rescued by @14-3-3&zgr;arm.PK@. ARB|14-3-3&zgr;arm.PK MD|@P{PZ}@ insertion into the first intron, 1633bp downstream of the splice |donor site of exon I'. TRN|FBti0009122 == P{PZ}14-3-3&zgr;07103 |BDGP:l(2)07103 MU|P-element activity PHC|lethal | recessive PHM|photoreceptor cell | somatic clone ALC|hypomorph PHI|Homozygous clones are recovered at low frequency and are small. Clones |in the eye frequently lack some photoreceptor cells in the ommatidia. SYN|l(2)-07103 } REFDSR { RDID|FBrf0095439 |Kockel et al. |1997 MD|@P{PZ}@ insertion in the 5' noncoding region. OTH|Insertion is 2.8kb downstream of the @Jra@ transcription unit. TRN|FBti0009122 == P{PZ}14-3-3&zgr;07103 |BDGP:l(2)07103 MU|P-element activity } REFDSR { RDID|FBrf0107534 |Zhang et al. |1999 TRN|FBti0009122 == P{PZ}14-3-3&zgr;07103 |BDGP:l(2)07103 GIC|suppressor | dominant of @Src42ASu(phl)1-1@ GII|Dominantly suppresses the ability of @Src42ASu(phl)1-1@ to suppress |the lethality of @phl1@/Y flies. SYN|l(2)K07103 } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 TRN|FBti0009122 == P{PZ}14-3-3&zgr;07103 |BDGP:l(2)07103 PHC|lethal | recessive SYN|l(2)k07103 } REFDSR { RDID|FBrf0145131 |Goldstein et al. |2001 PHC|(with Df(2R)X1) lethal SYN|l(2)07103 } REFDSR { RDID|FBrf0159690 |Chen et al. |2003 TRN|FBti0009122 == P{PZ}14-3-3&zgr;07103 |BDGP:l(2)07103 SYN|leo07103 } REFDSR { RDID|FBrf0187664 |Zhu et al. |2005 GIC|non-suppressor of visible phenotype of @btlScer\UAS.T:&lgr;\cI-DD@, @stumpsScer\UAS.T:Zzzz\FLAG@, @Scer\GAL4GMR.PF@ |non-enhancer of visible phenotype of @btlScer\UAS.T:&lgr;\cI-DD@, @stumpsScer\UAS.T:Zzzz\FLAG@, @Scer\GAL4GMR.PF@ GIA|non-suppressor of eye phenotype of @btlScer\UAS.T:&lgr;\cI-DD@, @stumpsScer\UAS.T:Zzzz\FLAG@, @Scer\GAL4GMR.PF@ |non-enhancer of eye phenotype of @btlScer\UAS.T:&lgr;\cI-DD@, @stumpsScer\UAS.T:Zzzz\FLAG@, @Scer\GAL4GMR.PF@ SYN|14-3-3&zgr;P07103 } SK|FBst0012335 |P{ry[+t7.2]=PZ}14-3-3zeta[07103] cn[1]/CyO; ry[506] } ALESR { ASYM|14-3-3&zgr;12BL SYN|leo12BL |14-3-312BL ID|FBal0065577 REF|FBrf0173208 |FBrf0098203 REFDSR { RDID|FBrf0098203 |Broadie et al. |1997 MD|One partially deleted insertion in the first intron and the second |partially deleted insertion resides in the original location. PRG|14-3-3&zgr;P1.3H MU|P-element activity PHC|lethal | embryonic stage | recessive |neurophysiology defective PHM|embryonic epidermis | lateral |embryonic epidermis | dorsal ALC|loss of function PHI|Homozygous embryos exhibit incomplete dorsal migration of the lateral |epidermis and failure of dorsal epidermal closure. CNS and neuromusculature |appear morphologically normal and the mutant embryos exhibit coordinated |muscle movements similar to those observed in wild-type locomotion. |Synaptogenesis at the neuromuscular junction (NMJ) is largely normal. |Embryos also exhibit near normal physiological development and basal |excitation-secretion function at the NMJ. The amplitude and frequency |of endogenous excitatory junctional currents (EJCs) is reduced relative |to wild type. This reduced function originates in a presynaptic defect, |basal presynaptic function is mildly impaired. MEJC (miniature EJCs) |amplitude is not altered. NMJ exhibits a transmission defect, the |calcium dependence curve is shifted to the right indicating a higher |level of external calcium is required to achieve the given level of |secretion. Synaptic transmission fidelity and fatigue resistance properties |are impaired. Short-term facilitation is strengthened but synaptic |augmentation an potentiation are disrupted. } REFDSR { RDID|FBrf0173208 |Benton and St. Johnston |2003 PHM|follicle cell | somatic clone PHI|Homozygous follicle cell clones are recovered only at a low frequency, |compared with sibling wild-type clones. Those mutant follicle cell |clones that do survive have severe morphological defects. SYN|leo12BL } } ALESR { ASYM|14-3-3&zgr;2.3 SYN|leo2.3 |leo23 |14-3-32.3 ID|FBal0059634 REF|FBrf0093395 |FBrf0139731 |FBrf0090801 REFDSR { RDID|FBrf0090801 |Skoulakis and Davis |1996 MD|Deletion of the @P{lArB}@ insertion and portions of genomic sequence. PRG|14-3-3&zgr;P1375 MU|&Dgr;2-3 PHC|(with 14-3-3&zgr;P1375) memory defective |viable |memory defective PHI|Exhibits a decrement in the 3 to 240 minute memory performance. Transheterozygotes |with @14-3-3&zgr;P1375@ show a highly significant reduction in 3 minute memory. |Odor avoidance (octanol and benzaldehyde) is normal. } REFDSR { RDID|FBrf0093395 |Chang and Rubin |1997 GIC2|visible | dominant with @14-3-3&egr;j2B10@/@14-3-3&egr;j2B10@ GIA2|ommatidium with @14-3-3&egr;j2B10@ |posterior crossvein with @14-3-3&egr;j2B10@ |eye with @14-3-3&egr;j2B10@ |photoreceptor cell with @14-3-3&egr;j2B10@ GII|@14-3-3&zgr;2.3@/+ @14-3-3&egr;j2B10@/@14-3-3&egr;j2B10@ flies have slightly |roughened eyes, a low penetrance of missing photoreceptors and a gap |in the posterior crossvein of the wings in more than 50% of cases. SYN|leo2.3 } REFDSR { RDID|FBrf0139731 |Philip et al. |2001 ARB|14-3-3&zgr;LI.15.hs |14-3-3&zgr;LII.2.hs MD|Deletion in the intron between exons 1' and 2 of @14-3-3&zgr;@. PHC|viable |learning defective |memory defective PHI|No neuroanatomical aberrations are evident during development of the |brain. Flies show reduced performance in a modified olfactory trap |assay, using geraniol as the attractive odor, both immediately after |training and 90 mins after training. SYN|leo23 } } ALESR { ASYM|14-3-3&zgr;5-11 SYN|5-11 |5.11 ID|FBal0157547 PHC|(with Df(2R)X1) lethal REF|FBrf0145131 |FBrf0178744 REFDSR { RDID|FBrf0145131 |Goldstein et al. |2001 MU|ethyl methanesulfonate \? |diepoxybutane \? |&ggr; ray \? PHC|(with Df(2R)X1) lethal SYN|5-11 } REFDSR { RDID|FBrf0178744 |Goldstein |2004.3.15 SYN|5.11 } } ALESR { ASYM|14-3-3&zgr;5.9 SYN|14-3-35.9 ID|FBal0059633 PHC|viable |memory defective PHI|Exhibits a decrement in the 3 minute memory performance. |Odor avoidance (octanol and benzaldehyde) is normal. REF|FBrf0090801 REFDSR { RDID|FBrf0090801 |Skoulakis and Davis |1996 MD|Deletion of the @P{lArB}@ insertion and portions of genomic sequence. PRG|14-3-3&zgr;P1375 MU|&Dgr;2-3 PHC|viable |memory defective PHI|Exhibits a decrement in the 3 minute memory performance. |Odor avoidance (octanol and benzaldehyde) is normal. } } ALESR { ASYM|14-3-3&zgr;7B SYN|14-3-37B ID|FBal0059632 PHC|viable |memory defective PHI|Exhibits a decrement in the 3 minute memory performance. |Odor avoidance (octanol and benzaldehyde) is normal. REF|FBrf0090801 REFDSR { RDID|FBrf0090801 |Skoulakis and Davis |1996 MD|Deletion of a portion of the @P{lArB}@ insertion and genomic sequence. PRG|14-3-3&zgr;P1375 TRN|FBti0012515 == P{?lArB}14-3-3&zgr;7B MU|&Dgr;2-3 PHC|viable |memory defective PHI|Exhibits a decrement in the 3 minute memory performance. |Odor avoidance (octanol and benzaldehyde) is normal. } } ALESR { ASYM|14-3-3&zgr;7BL SYN|14-3-37BL ID|FBal0065576 PHC|lethal | embryonic stage | recessive |neurophysiology defective PHM|embryonic epidermis | lateral |embryonic epidermis | dorsal ALC|hypomorph PHI|Homozygous embryos exhibit incomplete dorsal migration of the lateral |epidermis and failure of dorsal epidermal closure. CNS and neuromusculature |appear morphologically normal and the mutant embryos exhibit coordinated |muscle movements similar to those observed in wild-type locomotion. |Synaptogenesis at the neuromuscular junction (NMJ) is largely normal. |Embryos also exhibit near normal physiological development and basal |excitation-secretion function at the NMJ. The amplitude and frequency |of endogenous excitatory junctional currents (EJCs) is reduced relative |to wild type. This reduced function originates in a presynaptic defect, |basal presynaptic function is mildly impaired. MEJC (miniature EJCs) |amplitude is not altered. NMJ exhibits a transmission defect, the |calcium dependence curve is shifted to the right indicating a higher |level of external calcium is required to achieve the given level of |secretion. Synaptic transmission fidelity and fatigue resistance properties |are impaired. Short-term facilitation is strengthened but synaptic |augmentation an potentiation are disrupted. REF|FBrf0098203 REFDSR { RDID|FBrf0098203 |Broadie et al. |1997 MD|Partially deleted insertion at the original location and a 500bp deletion |in intron two. PRG|14-3-3&zgr;P1375 MU|P-element activity PHC|lethal | embryonic stage | recessive |neurophysiology defective PHM|embryonic epidermis | lateral |embryonic epidermis | dorsal ALC|hypomorph PHI|Homozygous embryos exhibit incomplete dorsal migration of the lateral |epidermis and failure of dorsal epidermal closure. CNS and neuromusculature |appear morphologically normal and the mutant embryos exhibit coordinated |muscle movements similar to those observed in wild-type locomotion. |Synaptogenesis at the neuromuscular junction (NMJ) is largely normal. |Embryos also exhibit near normal physiological development and basal |excitation-secretion function at the NMJ. The amplitude and frequency |of endogenous excitatory junctional currents (EJCs) is reduced relative |to wild type. This reduced function originates in a presynaptic defect, |basal presynaptic function is mildly impaired. MEJC (miniature EJCs) |amplitude is not altered. NMJ exhibits a transmission defect, the |calcium dependence curve is shifted to the right indicating a higher |level of external calcium is required to achieve the given level of |secretion. Synaptic transmission fidelity and fatigue resistance properties |are impaired. Short-term facilitation is strengthened but synaptic |augmentation an potentiation are disrupted. } } ALESR { ASYM|14-3-3&zgr;9.8 SYN|14-3-39.8 ID|FBal0059631 PHC|viable |memory defective PHI|Exhibits a decrement in the 3 minute memory performance. |Odor avoidance (octanol and benzaldehyde) is normal. REF|FBrf0090801 REFDSR { RDID|FBrf0090801 |Skoulakis and Davis |1996 MD|Deletion of the @P{lArB}@ insertion and portions of genomic sequence. PRG|14-3-3&zgr;P1375 MU|&Dgr;2-3 PHC|viable |memory defective PHI|Exhibits a decrement in the 3 minute memory performance. |Odor avoidance (octanol and benzaldehyde) is normal. } } ALESR { ASYM|14-3-3&zgr;E16 SYN|E-16 |14-3-3E16 ID|FBal0060814 DBA|NA:Y12573 REF|FBrf0099843 |FBrf0093549 |FBrf0093851 REFDSR { RDID|FBrf0093549 |Kockel et al. |1997 AMSO|The lethality is rescued by @14-3-3&zgr;tKa@ but not by @14-3-3&zgr;arm.PK@. ANRB|14-3-3&zgr;arm.PK ARB|14-3-3&zgr;tKa ARG2|FBgn0004907. MD|Imprecise excision of the @P{PZ}@ element, deleting 1957bp, including |exons I and I'. PRG|14-3-3&zgr;07103 MU|P-element activity PHC|lethal | recessive PHI|Homozygous clones are not recovered in a wild-type background or in |flies carrying @Ras85DV12.sev@, but are recovered in flies carrying |@phl::tor12D.hs.sev@. SYN|E-16 } REFDSR { RDID|FBrf0093851 |Mlodzik |1997.5.10 PRG|14-3-3&zgr;07103 MU|P-element activity } REFDSR { RDID|FBrf0099843 |Isaksson et al. |1997 GIA|suppressor | dominant of photoreceptor cell R1 | ectopic phenotype of @fafBX4@ |suppressor | dominant of photoreceptor cell R2 | ectopic phenotype of @fafBX4@ |suppressor | dominant of photoreceptor cell R3 | ectopic phenotype of @fafBX4@ |suppressor | dominant of photoreceptor cell R4 | ectopic phenotype of @fafBX4@ |suppressor | dominant of photoreceptor cell R5 | ectopic phenotype of @fafBX4@ |suppressor | dominant of photoreceptor cell R6 | ectopic phenotype of @fafBX4@ GII|The extra outer photoreceptor cell phenotype seen in @fafBX4@ homozygotes |is dominantly suppressed by @14-3-3&zgr;E16@, with the average number |of outer photoreceptor cells per ommatidium being reduced to 6.4. PHC|lethal | recessive } } ALESR { ASYM|14-3-3&zgr;E73 SYN|14-3-3E73 ID|FBal0063650 REF|FBrf0095439 REFDSR { RDID|FBrf0095439 |Kockel et al. |1997 MD|Deletion of the transcription start site and first exons. PRG|14-3-3&zgr;07103 MU|&Dgr;2-3 ABA|FBab0027145 == Df(2R)E73 SYN|unnamed } } ALESR { ASYM|14-3-3&zgr;EY03325 ID|FBal0157546 REF|FBrf0104946 |FBrf0132177 REFDSR { RDID|FBrf0104946 |FlyBase |1996- AMIS|Separable from: @CG2269EY03325@. TRN|FBti0038081 == P{EPgy2}14-3-3&zgr;EY03325 } REFDSR { RDID|FBrf0132177 |Gene Disruption Project members |2001- TRN|FBti0038081 == P{EPgy2}14-3-3&zgr;EY03325 MU|P-element activity } SK|FBst0015902 |y[1] w[67c23]; P{w[+mC] y[+mDint2]=EPgy2}CG2269[EY03325] P{EPgy2}14-3-3zeta[EY03325] } ALESR { ASYM|14-3-3&zgr;EY06147 ID|FBal0162866 PHC|viable |fertile REF|FBrf0132177 REFDSR { RDID|FBrf0132177 |Gene Disruption Project members |2001- TRN|FBti0039931 == P{EPgy2}14-3-3&zgr;EY06147 MU|P-element activity PHC|viable |fertile } } ALESR { ASYM|14-3-3&zgr;KG02642 ID|FBal0137676 REF|FBrf0132177 REFDSR { RDID|FBrf0132177 |Gene Disruption Project members |2001- TRN|FBti0023409 == P{SUPor-P}14-3-3&zgr;KG02642 |BDGP:KG02642 MU|P-element activity } } ALESR { ASYM|14-3-3&zgr;P1188 SYN|leoP1188 |P1188 |14-3-3P1188 ID|FBal0059629 REF|FBrf0173208 |FBrf0151902 |FBrf0098203 |FBrf0089671 |FBrf0158996 |FBrf0099365 |FBrf0129944 |FBrf0139731 |FBrf0090801 |FBrf0139721 REFDSR { RDID|FBrf0089671 |Han et al. |1996 PRG|FBti0004638 == FBti0000841 == P{lArB}A4.1M2 TRN|FBti0009360 == P{lArB}14-3-3&zgr;P1188 MU|&Dgr;2-3 SYN|unnamed } REFDSR { RDID|FBrf0090801 |Skoulakis and Davis |1996 PRG|FBti0004638 == FBti0000841 == P{lArB}A4.1M2 TRN|FBti0009360 == P{lArB}14-3-3&zgr;P1188 MU|&Dgr;2-3 PHC|lethal | embryonic stage | recessive PHI|Heterozygotes exhibit normal 3 minute memory performance. |Odor avoidance (octanol and benzaldehyde) is normal. SYN|unnamed } REFDSR { RDID|FBrf0098203 |Broadie et al. |1997 MD|@P{lArB}@ insertion in the first intron. TRN|FBti0009360 == P{lArB}14-3-3&zgr;P1188 PHC|lethal | recessive |neurophysiology defective ALC|hypomorph PHI|Embryos do not exhibit a dorsal closure defect. |The amplitude and frequency of endogenous excitatory junctional currents |(EJCs) is reduced relative to wild type and the NMJ exhibits a transmission |defect, the calcium dependence curve is shifted to the right indicating |a higher level of external calcium is required to achieve the given |level of secretion. } REFDSR { RDID|FBrf0099365 |Li et al. |1997 PHM|embryonic/first instar larval cuticle | germ-line clone |denticle belt | germ-line clone |syncytial blastoderm embryo | germ-line clone PHI|Embryos derived from homozygous female germline clones show a variable |phenotype that is not significantly different whether or not the embryos |contain a wild-type copy of @14-3-3&zgr;@ from the father. Approximately |50% of the embryos do not develop cuticles, and the remainder develop |cuticles with various segmentation defects including missing and/or |fused denticle bands. The Filzkorper appear normal. Approximately |50% of the embryos appear to stop development during the syncytial |blastoderm stage, and contain many fewer nuclei compared to wild-type. |Some of these nuclei appear fused. |18% of embryos carrying @14-3-3&zgr;hbNRE.RpII15@ and derived from homozygous |@14-3-3&zgr;P1188@ female germline clones have a wild-type anterior region |but are missing all or part of the posterior region. 56% of these |'anteriorly rescued' embryos have shortened Filzkorper. SYN|leoP1188 } REFDSR { RDID|FBrf0129944 |Li et al. |2000 SYN|leoP1188 } REFDSR { RDID|FBrf0139721 |Su et al. |2001 TRN|FBti0009360 == P{lArB}14-3-3&zgr;P1188 PHC|mitotic | recessive | maternal effect PHM|mitotic cell cycle | maternal effect PHI|Homozygous embryos show no apparent defects in the timing of mitotic |cycle 14 and show delayed mitosis after irradiation (as occurs in wild |type). |69 +/- 9% of mutant embryos derived from homozygous female germline |clones fail to cellularize. 54/59 of the embryos have defects in cell |division, including DNA bridges between telophase sister nuclei, asynchrony |in division within a single embryo, free microtubule-organizing centers |that are not associated with nuclei, loss of nuclei from the cortical |monolayer of nuclei and larger than normal yolk DNA masses. Chromosome |bridges interconnecting DNA masses are seen as early as telophase of |the fourth embryonic mitosis. Mitotic spindles do appear to be formed |in these embryos (as judged by the segregation of chromosome masses |that are still linked by DNA bridges to opposite spindle poles), and |attempts at the formation of mid-bodies are seen between segregating |nuclei, despite the presence of chromosome bridges. |Approximately 30% of embryos cellularize. These embryos have severe |gastrulation defects. SYN|P1188 } REFDSR { RDID|FBrf0139731 |Philip et al. |2001 ANRB|(with 14-3-3&zgr;P1375) 14-3-3&zgr;LII.2.hs |(with 14-3-3&zgr;P2335) 14-3-3&zgr;LII.2.hs |14-3-3&zgr;LI.15.hs |14-3-3&zgr;LII.2.hs APRB|(with 14-3-3&zgr;P1375) 14-3-3&zgr;LI.15.hs |(with 14-3-3&zgr;P2335) 14-3-3&zgr;LI.15.hs ARB|(with 14-3-3&zgr;P1375) 14-3-3&zgr;LI.15.hs |(with 14-3-3&zgr;P2335) 14-3-3&zgr;LI.15.hs MD|Insertion, in forward orientation, of @P{lArB}@ into the intron between |exons 1' and 2 of @14-3-3&zgr;@. TRN|FBti0009360 == P{lArB}14-3-3&zgr;P1188 PHC|lethal |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;P1375) viable |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;P1375) learning defective |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs, 14-3-3&zgr;P1375) viable |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs, 14-3-3&zgr;P1375) learning defective |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;P2335) viable |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;P2335) learning defective |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs, 14-3-3&zgr;P2335) viable |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs, 14-3-3&zgr;P2335) learning defective PHI|Flies rescued from lethality by @14-3-3&zgr;LI.15.hs@ or @14-3-3&zgr;LI.15.hs@ |and @14-3-3&zgr;LII.2.hs@ show a 25-30% decrement in olfactory learning, |comparable to that of (rescued) @14-3-3&zgr;2.3@. The restoration |of learning by the transgenes decays back to mutant levels 60-70 hr |later. SYN|leoP1188 } REFDSR { RDID|FBrf0151902 |Benton et al. |2002 TRN|FBti0009360 == P{lArB}14-3-3&zgr;P1188 GIA2|oocyte | germ-line clone with @14-3-3&egr;S-1259@/+ |oocyte | germ-line clone with @14-3-3&egr;j2B10@/+ GIA|enhancer of nurse cell | ectopic | germ-line clone phenotype of @14-3-3&egr;j2B10@ |enhancer of oocyte | germ-line clone phenotype of @14-3-3&egr;j2B10@ GII|Many @14-3-3&zgr;P1188@ germ-line clones in @14-3-3&egr;j2B10@/+ |females have defects in oocyte specification and polarization. |Many @14-3-3&zgr;P1188@ germ-line clones in @14-3-3&egr;S-1259@/+ |females have defects in oocyte specification. |The penetrance of the oocyte to nurse cell transformation phenotype |seen in @14-3-3&egr;j2B10@ germ-line clones (80% n=106) is dominantly |enhanced to 100% by @14-3-3&zgr;P1188@. PHC|lethal PHI|@14-3-3&zgr;P1188@ germ-line clones do not exhibit defects in |oocyte specification or polarization. SYN|leoP1188 } REFDSR { RDID|FBrf0158996 |Li and Li |2003 GIA|suppressor | maternal effect of embryonic/first instar larval cuticle | maternal effect phenotype of @tor12D@ SYN|leoP1188 } REFDSR { RDID|FBrf0173208 |Benton and St. Johnston |2003 GIA2|(with 14-3-3&zgr;P1375) follicle cell with @14-3-3&egr;j2B10@/+ GII|Follicular epithelium morphogenesis is normal in @14-3-3&zgr;P1188@/@14-3-3&zgr;P1375@ |; @14-3-3&egr;j2B10@/+ egg chambers up to stage 4, but the follicle |cells subsequently lose their regular cuboidal shape. PHM|follicle cell | somatic clone PHI|Large homozygous follicle cell clones show dramatic defects in tissue |organization, forming multilayers of morphologically abnormal cells |that often fail to encapsulate germline cysts properly. Smaller homozygous |follicle cell clones that arise after epithelium formation have milder |and less penetrant defects in morphology and polarity. SYN|leoP1188 } } ALESR { ASYM|14-3-3&zgr;P1375 SYN|leoP1375 |14-3-3P1375 ID|FBal0059628 REF|FBrf0173208 |FBrf0098203 |FBrf0089671 |FBrf0139731 |FBrf0090801 REFDSR { RDID|FBrf0089671 |Han et al. |1996 PRG|FBti0004638 == FBti0000841 == P{lArB}A4.1M2 TRN|FBti0009359 == P{lArB}14-3-3&zgr;P1375 MU|&Dgr;2-3 SYN|unnamed } REFDSR { RDID|FBrf0090801 |Skoulakis and Davis |1996 PRG|FBti0004638 == FBti0000841 == P{lArB}A4.1M2 TRN|FBti0009359 == P{lArB}14-3-3&zgr;P1375 MU|&Dgr;2-3 PHC|lethal | embryonic stage | recessive |(with 14-3-3&zgr;2.3) memory defective |(with 14-3-3&zgr;X1) memory defective PHI|Heterozygotes exhibit normal 3 minute memory performance. Transheterozygotes |with @14-3-3&zgr;X1@ or @14-3-3&zgr;2.3@ show a highly significant reduction in |3 minute memory. |Odor avoidance (octanol and benzaldehyde) is normal. SYN|unnamed } REFDSR { RDID|FBrf0098203 |Broadie et al. |1997 MD|@P{lArB}@ insertion in the first intron. TRN|FBti0009359 == P{lArB}14-3-3&zgr;P1375 PHC|lethal | recessive } REFDSR { RDID|FBrf0139731 |Philip et al. |2001 ANRB|(with 14-3-3&zgr;P1188) 14-3-3&zgr;LII.2.hs |(with 14-3-3&zgr;P2335) 14-3-3&zgr;LII.2.hs APRB|(with 14-3-3&zgr;P1188) 14-3-3&zgr;LI.15.hs |14-3-3&zgr;LI.15.hs ARB|(with 14-3-3&zgr;P1188) 14-3-3&zgr;LI.15.hs |(with 14-3-3&zgr;P2335) 14-3-3&zgr;LI.15.hs |14-3-3&zgr;LI.15.hs |14-3-3&zgr;LII.2.hs MD|Insertion, in forward orientation, of @P{lArB}@ into the intron between |exons 1' and 2 of @14-3-3&zgr;@. TRN|FBti0009359 == P{lArB}14-3-3&zgr;P1375 PHC|lethal |(with 14-3-3&zgr;LI.15.hs) viable |(with 14-3-3&zgr;LI.15.hs) learning defective |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs) viable |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs) learning defective |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;P1188) viable |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;P1188) learning defective |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs, 14-3-3&zgr;P1188) viable |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs, 14-3-3&zgr;P1188) learning defective PHI|Flies rescued from lethality by @14-3-3&zgr;LI.15.hs@ or @14-3-3&zgr;LI.15.hs@ |and @14-3-3&zgr;LII.2.hs@ show a 25-30% decrement in olfactory learning, |comparable to that of (rescued) @14-3-3&zgr;2.3@. The restoration |of learning by the transgenes decays back to mutant levels 60-70 hr |later. SYN|leoP1375 } REFDSR { RDID|FBrf0173208 |Benton and St. Johnston |2003 GIA2|(with 14-3-3&zgr;P1188) follicle cell with @14-3-3&egr;j2B10@/+ GII|Follicular epithelium morphogenesis is normal in @14-3-3&zgr;P1188@/@14-3-3&zgr;P1375@ |; @14-3-3&egr;j2B10@/+ egg chambers up to stage 4, but the follicle |cells subsequently lose their regular cuboidal shape. SYN|leoP1375 } } ALESR { ASYM|14-3-3&zgr;P2335 SYN|leoP2335 ID|FBal0134434 PHC|lethal |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;P1188) viable |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;P1188) learning defective |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs, 14-3-3&zgr;P1188) viable |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs, 14-3-3&zgr;P1188) learning defective PHI|Flies rescued from lethality by @14-3-3&zgr;LI.15.hs@ or @14-3-3&zgr;LI.15.hs@ |and @14-3-3&zgr;LII.2.hs@ show a 25-30% decrement in olfactory learning, |comparable to that of (rescued) @14-3-3&zgr;2.3@. The restoration |of learning by the transgenes decays back to mutant levels 60-70 hr |later. REF|FBrf0139731 REFDSR { RDID|FBrf0139731 |Philip et al. |2001 ANRB|(with 14-3-3&zgr;P1188) 14-3-3&zgr;LII.2.hs |(with 14-3-3&zgr;P1375) 14-3-3&zgr;LII.2.hs |14-3-3&zgr;LI.15.hs |14-3-3&zgr;LII.2.hs APRB|(with 14-3-3&zgr;P1188) 14-3-3&zgr;LI.15.hs ARB|(with 14-3-3&zgr;P1188) 14-3-3&zgr;LI.15.hs |(with 14-3-3&zgr;P1375) 14-3-3&zgr;LI.15.hs MD|Insertion, in forward orientation, of @P{?}@ into the intron between |exons 1' and 2 of @14-3-3&zgr;@. TRN|FBti0023266 == P{?}14-3-3&zgr;P2335 MU|P-element activity PHC|lethal |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;P1188) viable |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;P1188) learning defective |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs, 14-3-3&zgr;P1188) viable |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs, 14-3-3&zgr;P1188) learning defective PHI|Flies rescued from lethality by @14-3-3&zgr;LI.15.hs@ or @14-3-3&zgr;LI.15.hs@ |and @14-3-3&zgr;LII.2.hs@ show a 25-30% decrement in olfactory learning, |comparable to that of (rescued) @14-3-3&zgr;2.3@. The restoration |of learning by the transgenes decays back to mutant levels 60-70 hr |later. SYN|leoP2335 } } ALESR { ASYM|14-3-3&zgr;P2355 SYN|leoP2355 |14-3-3P2355 ID|FBal0062288 PHC|lethal | recessive PHI|Heterozygosity for @14-3-3&zgr;P2355@ does not alter the @Ras85DV12.sev@ |phenotype. REF|FBrf0093395 REFDSR { RDID|FBrf0093395 |Chang and Rubin |1997 GIC2|lethal | dominant with @14-3-3&egr;j2B10@/@14-3-3&egr;j2B10@ PHC|lethal | recessive PHI|Heterozygosity for @14-3-3&zgr;P2355@ does not alter the @Ras85DV12.sev@ |phenotype. SYN|leoP2355 } } ALESR { ASYM|14-3-3&zgr;P1.3H SYN|14-3-3P1.3H ID|FBal0059630 REF|FBrf0098203 |FBrf0090801 REFDSR { RDID|FBrf0090801 |Skoulakis and Davis |1996 MD|@P{lArB}@ insertion into the second intron. OTH|Weak @14-3-3&zgr;@ mutation. PRG|14-3-3&zgr;P1375 TRN|FBti0009381 == P{lArB}14-3-3&zgr;P1.3H MU|&Dgr;2-3 PHC|viable |memory defective PHI|Exhibits a decrement in the 3 and 45 minute memory performance. Memory |performance at 90 and 240 minutes is the same as controls. |Odor avoidance (octanol and benzaldehyde) is normal. } REFDSR { RDID|FBrf0098203 |Broadie et al. |1997 MD|Hop of the @P{lArB}@ insertion into intron 2. PRG|14-3-3&zgr;P1375 TRN|FBti0009381 == P{lArB}14-3-3&zgr;P1.3H MU|P-element activity PHC|viable } } ALESR { ASYM|14-3-3&zgr;R1 SYN|14-3-3R1 ID|FBal0059627 PHC|viable PHI|Normal memory performance over 3 to 240 minutes. |Odor avoidance (octanol and benzaldehyde) is normal. REF|FBrf0090801 REFDSR { RDID|FBrf0090801 |Skoulakis and Davis |1996 MD|Precise excision of the @P{lArB}@ insertion. PRG|14-3-3&zgr;P1375 MU|&Dgr;2-3 PHC|viable PHI|Normal memory performance over 3 to 240 minutes. |Odor avoidance (octanol and benzaldehyde) is normal. } } ALESR { ASYM|14-3-3&zgr;R2 SYN|14-3-3R2 ID|FBal0059626 PHC|viable PHI|Normal 3 minute memory performance. |Odor avoidance (octanol and benzaldehyde) is normal. REF|FBrf0090801 REFDSR { RDID|FBrf0090801 |Skoulakis and Davis |1996 MD|Precise excision of the @P{lArB}@ insertion. PRG|14-3-3&zgr;P1375 MU|&Dgr;2-3 PHC|viable PHI|Normal 3 minute memory performance. |Odor avoidance (octanol and benzaldehyde) is normal. } } ALESR { ASYM|14-3-3&zgr;unspecified ID|FBal0157545 REF|FBrf0179048 } ALESR { ASYM|14-3-3&zgr;X1 SYN|leoX.1 |leoX1 |14-3-3X1 ID|FBal0059625 REF|FBrf0093395 |FBrf0139731 |FBrf0090801 REFDSR { RDID|FBrf0090801 |Skoulakis and Davis |1996 MD|Deletion of the @P{lArB}@ insertion and portions of genomic sequence. PRG|14-3-3&zgr;P1375 MU|&Dgr;2-3 PHC|(with 14-3-3&zgr;P1375) memory defective |viable |memory defective PHI|Exhibits a decrement in the 3 minute memory performance. Transheterozygotes |with @14-3-3&zgr;P1375@ show a highly significant reduction in 3 minute memory. |Odor avoidance (octanol and benzaldehyde) is normal. } REFDSR { RDID|FBrf0093395 |Chang and Rubin |1997 GIC2|visible | dominant with @14-3-3&egr;j2B10@/@14-3-3&egr;j2B10@ GIA2|ommatidium with @14-3-3&egr;j2B10@ |posterior crossvein with @14-3-3&egr;j2B10@ |eye with @14-3-3&egr;j2B10@ |photoreceptor cell with @14-3-3&egr;j2B10@ GII|@14-3-3&zgr;X1@/+ @14-3-3&egr;j2B10@/@14-3-3&egr;j2B10@ flies have slightly |roughened eyes, a low penetrance of missing photoreceptors and a gap |in the posterior crossvein of the wings in more than 50% of cases. SYN|leoX.1 } REFDSR { RDID|FBrf0139731 |Philip et al. |2001 ARB|14-3-3&zgr;LI.15.hs |14-3-3&zgr;LII.2.hs MD|Deletion in the intron between exons 1' and 2 of @14-3-3&zgr;@. PHC|viable |learning defective |memory defective PHI|No neuroanatomical aberrations are evident during development of the |brain. Flies show reduced performance in a modified olfactory trap |assay, using geraniol as the attractive odor, both immediately after |training and 90 mins after training. SYN|leoX1 } } ALESR { ASYM|14-3-3&zgr;a.sev SYN|14-3-3a.sev ID|FBal0062287 PHM|photoreceptor cell PHI|Mode of assay: In transgenic Drosophila (intraspecific) |Flies carrying @14-3-3&zgr;a.sev@ have a weakly penetrant loss of photoreceptor |cell phenotype. The outer photoreceptor cells are more severely affected. REF|FBrf0093549 REFDSR { RDID|FBrf0093549 |Kockel et al. |1997 NAM|antisense sevenless promoter construct MD|Construct: A 1.0kb @14-3-3&zgr;@ cDNA fragment containing the complete open reading |frame is expressed in the antisense orientation under the control of |a @sev@ enhancer. MU|in vitro construct | regulatory fusion CNS|FBtp0008239 == P{sE.anti-14-3-3} PHM|photoreceptor cell PHI|Mode of assay: In transgenic Drosophila (intraspecific) |Flies carrying @14-3-3&zgr;a.sev@ have a weakly penetrant loss of photoreceptor |cell phenotype. The outer photoreceptor cells are more severely affected. } } ALESR { ASYM|14-3-3&zgr;arm.PK SYN|14-3-3arm.PK ID|FBal0062286 PHC|wild-type PHI|Mode of assay: In transgenic Drosophila (intraspecific) REF|FBrf0093549 REFDSR { RDID|FBrf0093549 |Kockel et al. |1997 NAM|armadillo promoter construct of Kockel ARS|14-3-3&zgr;07103 AFS|14-3-3&zgr;E16 MD|Construct: A 1.0kb @14-3-3&zgr;@ cDNA fragment containing the complete open reading |frame is expressed under the control of an @arm@ promoter. MU|in vitro construct | regulatory fusion CNS|FBtp0015025 == P{arm-14-3-3&zgr;.K} PHC|wild-type PHI|Mode of assay: In transgenic Drosophila (intraspecific) } } ALESR { ASYM|14-3-3&zgr;hbNRE.RpII15 SYN|14-3-3hbNRE.RpII15 ID|FBal0083670 PHM|embryo | posterior | germ-line clone |filzkorper | germ-line clone PHI|Mode of assay: In transgenic Drosophila (intraspecific) |18% of embryos carrying @14-3-3&zgr;hbNRE.RpII15@ and derived from homozygous |@14-3-3&zgr;P1188@ female germline clones have a wild-type anterior region |but are missing all or part of the posterior region. 56% of these |'anteriorly rescued' embryos have shortened Filzkorper. REF|FBrf0099365 REFDSR { RDID|FBrf0099365 |Li et al. |1997 MD|Construct: A 1.4kb @RpII15@ promoter fragment drives expression of a 780bp @14-3-3&zgr;@ |cDNA which has a 150bp fragment from the @hb@ 3' untranslated region, |containing a @nos@-response element (NRE), fused to its 3' end. MU|in vitro construct | regulatory fusion CNS|FBtp0009043 == P{RpII15-14-3-3.hbNRE} PHM|embryo | posterior | germ-line clone |filzkorper | germ-line clone PHI|Mode of assay: In transgenic Drosophila (intraspecific) |18% of embryos carrying @14-3-3&zgr;hbNRE.RpII15@ and derived from homozygous |@14-3-3&zgr;P1188@ female germline clones have a wild-type anterior region |but are missing all or part of the posterior region. 56% of these |'anteriorly rescued' embryos have shortened Filzkorper. } } ALESR { ASYM|14-3-3&zgr;hs.PL SYN|14-3-3hs.PL ID|FBal0083669 PHM|denticle belt PHI|Mode of assay: In transgenic Drosophila (intraspecific) |Overexpression of @14-3-3&zgr;hs.PL@ in wild-type embryos results in deletion |of denticle bands. REF|FBrf0099365 REFDSR { RDID|FBrf0099365 |Li et al. |1997 NAM|heat shock construct of Li MD|Construct: A 780bp @14-3-3&zgr;@ cDNA is expressed under the control of an Hsp70 promoter. MU|in vitro construct | regulatory fusion CNS|FBtp0009042 == P{hs-14-3-3.L} GIA|suppressor | partially of embryonic/first instar larval cuticle phenotype of @torrv66@ GII|Overexpression of @14-3-3&zgr;hs.PL@ partly rescues the cuticle of |embryos derived from @torrv66@ females. PHM|denticle belt PHI|Mode of assay: In transgenic Drosophila (intraspecific) |Overexpression of @14-3-3&zgr;hs.PL@ in wild-type embryos results in deletion |of denticle bands. } } ALESR { ASYM|14-3-3&zgr;LI.15.hs ID|FBal0134436 PHC|(with 14-3-3&zgr;P1375) learning defective |(with 14-3-3&zgr;P1375) viable |wild-type PHI|Mode of assay: In transgenic Drosophila (intraspecific) REF|FBrf0139731 REFDSR { RDID|FBrf0139731 |Philip et al. |2001 AFS|14-3-3&zgr;P1188 |14-3-3&zgr;P2335 APR|(with 14-3-3&zgr;LII.2.hs) 14-3-3&zgr;P1375 |(with 14-3-3&zgr;LII.2.hs) 14-3-3&zgr;P1375/14-3-3&zgr;P1188 |(with 14-3-3&zgr;LII.2.hs) 14-3-3&zgr;P1375/14-3-3&zgr;P2335 |(with 14-3-3&zgr;LII.2.hs) 14-3-3&zgr;P1188/14-3-3&zgr;P2335 |14-3-3&zgr;P1188/14-3-3&zgr;P2335 |14-3-3&zgr;P1375 |14-3-3&zgr;P1375/14-3-3&zgr;P1188 ARS|14-3-3&zgr;2.3 |14-3-3&zgr;P1188/14-3-3&zgr;P2335 |14-3-3&zgr;P1375/14-3-3&zgr;P1188 |14-3-3&zgr;P1375/14-3-3&zgr;P2335 |14-3-3&zgr;X1 |14-3-3&zgr;P1375 AMSO|Induction with two 30 min heat shocks daily through embryonic, larval |and pupal stages rescues the lethal phenotype of @14-3-3&zgr;P1375@. |A single heat shock daily can also rescue to adulthood. |Shows heat-shock specific rescue of the learning and memory defects |of @14-3-3&zgr;X1@ and @14-3-3&zgr;2.3@. |Flies rescued from lethality by @14-3-3&zgr;LI.15.hs@ or @14-3-3&zgr;LI.15.hs@ |and @14-3-3&zgr;LII.2.hs@ show a 25-30% decrement in olfactory learning, |comparable to that of (rescued) @14-3-3&zgr;2.3@. The restoration |of learning by the transgenes decays back to mutant levels 60-70 hr |later. MD|Construct: Expression of a @14-3-3&zgr;@ cDNA exons 1-6,7 is driven by a heat |shock promoter. MU|in vitro construct | regulatory fusion CNS|FBtp0015596 == P{hs-14-3-3&zgr;.LI.15} PHC|(with 14-3-3&zgr;P1375) learning defective |(with 14-3-3&zgr;P1375) viable |wild-type PHI|Mode of assay: In transgenic Drosophila (intraspecific) } } ALESR { ASYM|14-3-3&zgr;LII.2.hs ID|FBal0134435 PHC|wild-type PHI|Mode of assay: In transgenic Drosophila (intraspecific) REF|FBrf0139731 REFDSR { RDID|FBrf0139731 |Philip et al. |2001 AFS|14-3-3&zgr;P1188 |14-3-3&zgr;P1188/14-3-3&zgr;P2335 |14-3-3&zgr;P1375/14-3-3&zgr;P1188 |14-3-3&zgr;P1375/14-3-3&zgr;P2335 |14-3-3&zgr;P2335 APR|(with 14-3-3&zgr;LI.15.hs) 14-3-3&zgr;P1375 |(with 14-3-3&zgr;LI.15.hs) 14-3-3&zgr;P1375/14-3-3&zgr;P1188 |(with 14-3-3&zgr;LI.15.hs) 14-3-3&zgr;P1375/14-3-3&zgr;P2335 |(with 14-3-3&zgr;LI.15.hs) 14-3-3&zgr;P1188/14-3-3&zgr;P2335 ARS|14-3-3&zgr;2.3 |14-3-3&zgr;X1 |14-3-3&zgr;P1375 AMSO|Induction with two 30 min heat shocks daily through embryonic, larval |and pupal stages rescues the lethal phenotype of @14-3-3&zgr;P1375@. |A single heat shock daily can also rescue to adulthood. |Shows heat-shock specific rescue of the learning and memory defects |of @14-3-3&zgr;X1@ and @14-3-3&zgr;2.3@. |Flies rescued from lethality by @14-3-3&zgr;LI.15.hs@ and @14-3-3&zgr;LII.2.hs@ |show a 25-30% decrement in olfactory learning, comparable to that of |(rescued) @14-3-3&zgr;2.3@. The restoration of learning by the transgenes |decays back to mutant levels 60-70 hr later. MD|Construct: Expression of a @14-3-3&zgr;@ cDNA exons 1-6',7 is driven by a heat |shock promoter. MU|in vitro construct | regulatory fusion CNS|FBtp0015595 == P{hs-14-3-3&zgr;.LII.2} PHC|wild-type PHI|Mode of assay: In transgenic Drosophila (intraspecific) } } ALESR { ASYM|14-3-3&zgr;sev.PK SYN|14-3-3sev.PK ID|FBal0062285 PHI|Mode of assay: In transgenic Drosophila (intraspecific) |Flies carrying @14-3-3&zgr;a.sev@ appear wild-type. REF|FBrf0093549 REFDSR { RDID|FBrf0093549 |Kockel et al. |1997 NAM|sevenless promoter construct of Kockel MD|Construct: A 1.0kb @14-3-3&zgr;@ cDNA fragment containing the complete open reading |frame is expressed in the sense orientation under the control of a |@sev@ enhancer. MU|in vitro construct | regulatory fusion CNS|FBtp0008238 == P{sE.14-3-3} PHI|Mode of assay: In transgenic Drosophila (intraspecific) |Flies carrying @14-3-3&zgr;a.sev@ appear wild-type. } } ALESR { ASYM|14-3-3&zgr;tKa SYN|14-3-3tKa ID|FBal0062284 PHC|wild-type PHI|Mode of assay: In transgenic Drosophila (intraspecific) REF|FBrf0093549 REFDSR { RDID|FBrf0093549 |Kockel et al. |1997 ARS|14-3-3&zgr;E16 MD|Construct: 13.5kb genomic fragment containing the entire coding region and 1.7kb |of upstream and downstream sequences. MU|in vitro construct | genomic fragment CNS|FBtp0008237 == P{14-3-3&zgr;tKa} PHC|wild-type PHI|Mode of assay: In transgenic Drosophila (intraspecific) } } ALESR { ASYM|14-3-3&zgr;+ ID|FBal0066544 CLA|wild-type generic REF|FBrf0105495 } IFL|../torstoll/leonrd1.htm SK|FBst0012335 |P{ry[+t7.2]=PZ}14-3-3zeta[07103] cn[1]/CyO; ry[506] |FBst0015902 |y[1] w[67c23]; P{w[+mC] y[+mDint2]=EPgy2}CG2269[EY03325] P{EPgy2}14-3-3zeta[EY03325] SKC|2 } # EOR GENR { RETE|ID 1 FBgn0010340 CLA 1 Gene NAM 1 upstream of RpII140 GSYM 1 140up DT 1 25 Nov 05 RESZ 6741 PDOM 1 INTERPRO:IPR003397 == Mitochondrial import inner membrane translocase, subunit Tim17/22 PTD 1 DBA 16 FNC 2 development CEL 1 mitochondrial inner membrane CLOC 1 88A9 ALESR 6 REF 16 GSYM|140up PTD ARGS DT|25 Nov 05 ID|FBgn0010340 UAB|Deficiency: Df(3R)red-P52 |Duplication: Dp(3;2)ry+ (inferred from cytology) SYN|CG9852 |DmRP140-upstream |l(3)Z6 |DmRP140up |l(3)88Ba ID2|FBgn0004843 NAM|upstream of RpII140 CLOC|88A9 |Limits computationally determined from genome sequence between @P{PZ}flfl01949@ and @P{lacW}trxj14A6@&@P{PZ}trx00347@ FNC|development ; GO:0007275 |protein transport ; GO:0015031 CEL|mitochondrial inner membrane ; GO:0005743 PDOM|IPR003397 == Mitochondrial import inner membrane translocase, subunit Tim17/22 GLOC|Maps to the right of RpII140: 0.02 GLC|@140upZ6@ maps 0.02cM from @RpII140Z24@, with @140up@ probably |lying proximal to @RpII140@. ENZ|protein transporter activity ; GO:0008565 |protein transporter activity ; GO:0008565 | inferred from electronic annotation DBA|NA:AA941870 |BDGP-DGC:LD27182 |NA:AC007441 |BDGP:BACR10E03 |NA:AC007904 |BDGP:BACR01H04 |NA:AE003703 |PA:AAF55023 |NA:AW942742 |BDGP-DGC:LD27182 |NA:AY058577 |PA:AAL13806 |BDGP-DGC:LD27182 |NA:M62973 |NA:M62975 |PA:AAD40352 PAC|UniProt_Swiss_Prot:P81928 PHP|All known alleles are recessive lethals. ASQ|FBan0009852 REF { REFM|FBrf0159398 |FlyBase Curators |2002- |9 REFM|FBrf0120782 |Sitzler |1999.8.31 |9 REFM|FBrf0058600 |Hamilton et al. |1993 |0 REFM|FBrf0120781 |Sitzler |1999.8.31 |9 REFM|FBrf0152147 |Ceriani et al. |2002 |0 REFM|FBrf0126702 |Zheng |1999.11 |9 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0056267 |Mortin et al. |1992 |0 REFM|FBrf0054010 |Sitzler et al. |1991 |0 REFM|FBrf0092726 |Wiedemann et al. |1997 |0 REFM|FBrf0141598 |Wahlstrom et al. |2001 |0 REFM|FBrf0058349 |Oldenburg et al. |1993 |1 REFM|FBrf0179797 |Bloomington Drosophila Stock Center |2004.11.6 |9 REFM|FBrf0174215 |FlyBase Curators et al. |2004- |9 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0054607 |Breen and Harte |1991 |0 } REFDSR { RDID|FBrf0054010 |Sitzler et al. |1991 FNC|development ; GO:0007275 | inferred from mutant phenotype SYN|DmRP140-upstream } REFDSR { RDID|FBrf0054607 |Breen and Harte |1991 BMD|Df(3R)JY19 BMD|Df(3R)red-P52 BMDD|Df(3R)JY28 BMDD|Df(3R)red-P6 BMDD|Df(3R)red-P93 BMDD|Df(3R)red2l BMDD|Df(3R)su(Hw)V BMDD|Df(3R)trxE12 BMDD|T(Y;3)redP4 SYN|l(3)Z6 } REFDSR { RDID|FBrf0056267 |Mortin et al. |1992 BMD|Df(3R)red-P1 BMD|Df(3R)red-P52 BMDD|Df(3R)293&ggr;5 BMDD|Df(3R)red-P6 BMDD|Df(3R)red-P93 BMDD|Df(3R)su(Hw)V } REFDSR { RDID|FBrf0058600 |Hamilton et al. |1993 GLOC|Maps to the right of RpII140: 0.02 GLC|@140upZ6@ maps 0.02cM from @RpII140Z24@, with @140up@ probably |lying proximal to @RpII140@. } REFDSR { RDID|FBrf0092726 |Wiedemann et al. |1997 PHP|Sequences important for the transcription of @RpII140@ are located |in the untranslated leader of the divergently transcribed @140up@ gene. SYN|DmRP140up } REFDSR { RDID|FBrf0105495 |FlyBase |1992- MD|Maps to clone: BACR01H04 |Maps to clone: BACR10E03 } REFDSR { RDID|FBrf0120781 |Sitzler |1999.8.31 SYN|unnamed } REFDSR { RDID|FBrf0120782 |Sitzler |1999.8.31 MD|Gene order: Overall orientation not stated: 140up- RpII140+ SYN|DmRP140-upstream } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: LD27182 (BDGP-DGC) } REFDSR { RDID|FBrf0126702 |Zheng |1999.11 AM|Source for identity of: 140up CG9852 } REFDSR { RDID|FBrf0141598 |Wahlstrom et al. |2001 MD|Gene order: Overall orientation not stated: Abi- twf+ 140up- } REFDSR { RDID|FBrf0152147 |Ceriani et al. |2002 } REFDSR { RDID|FBrf0174215 |FlyBase Curators et al. |2004- ENZ|protein transporter activity ; GO:0008565 | inferred from electronic annotation FNC|protein transport ; GO:0015031 | inferred from electronic annotation CEL|mitochondrial inner membrane ; GO:0005743 | inferred from electronic annotation } ALESR { ASYM|140upf07279 ID|FBal0162865 REF|FBrf0179797 REFDSR { RDID|FBrf0179797 |Bloomington Drosophila Stock Center |2004.11.6 TRN|FBti0042654 == PBac{WH}140upf07279 MU|piggyBac transposase } } ALESR { ASYM|140upM13 ID|FBal0031933 PHC|lethal | recessive REF|FBrf0056267 REFDSR { RDID|FBrf0056267 |Mortin et al. |1992 MU|ethyl methanesulfonate PHC|lethal | recessive } } ALESR { ASYM|140upZ6 SYN|Z6 ID|FBal0031936 PHC|lethal | recessive REF|FBrf0054607 |FBrf0058600 |FBrf0056267 REFDSR { RDID|FBrf0056267 |Mortin et al. |1992 MU|ethyl methanesulfonate PHC|lethal | recessive } REFDSR { RDID|FBrf0058600 |Hamilton et al. |1993 SYN|Z6 } } ALESR { ASYM|140upZ29 SYN|Z29 ID|FBal0031934 PHC|lethal | recessive REF|FBrf0058600 |FBrf0056267 REFDSR { RDID|FBrf0056267 |Mortin et al. |1992 MU|ethyl methanesulfonate PHC|lethal | recessive } REFDSR { RDID|FBrf0058600 |Hamilton et al. |1993 SYN|Z29 } } ALESR { ASYM|140upZ30 SYN|Z30 ID|FBal0031935 PHC|lethal | recessive REF|FBrf0058600 |FBrf0056267 REFDSR { RDID|FBrf0056267 |Mortin et al. |1992 MU|ethyl methanesulfonate PHC|lethal | recessive } REFDSR { RDID|FBrf0058600 |Hamilton et al. |1993 SYN|Z30 } } ALESR { ASYM|140up+ ID|FBal0066317 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0067636 CLA 1 Gene NAM 1 146y GSYM 1 146y DT 1 25 Nov 05 RESZ 2199 ALESR 2 REF 1 GSYM|146y DT|25 Nov 05 ID|FBgn0067636 NAM|146y REF { REFM|FBrf0141372 |Ejima et al. |2001 |0 } ALESR { ASYM|146y146y SYN|146y ID|FBal0151007 PHC|viable |fertile |courtship defective | female PHI|@146y146y@ virgin females show elevated ovulation; 30% of the virgin |females show ovulation (compared to 0% of virgin Oregon-R females). |The flies show no obvious defects in viability, fertility, morphology |or locomotor activity. |The courtship index observed when @146y146y@ virgin females are mated |to wild-type males is lower than that seen when wild-type virgin females |are mated to wild-type males, but is higher than that seen when wild-type |mated females are mated to wild-type males. @146y146y@ mutant virgin |females show ovipositor extrusion towards courting wild-type males |(this extrusion behavior is normally observed in mated wild-type females |but not in virgin wild-type females). REF|FBrf0141372 REFDSR { RDID|FBrf0141372 |Ejima et al. |2001 TRN|FBti0037976 == P{GawB}146y146y MU|P-element activity PHC|viable |fertile |courtship defective | female PHI|@146y146y@ virgin females show elevated ovulation; 30% of the virgin |females show ovulation (compared to 0% of virgin Oregon-R females). |The flies show no obvious defects in viability, fertility, morphology |or locomotor activity. |The courtship index observed when @146y146y@ virgin females are mated |to wild-type males is lower than that seen when wild-type virgin females |are mated to wild-type males, but is higher than that seen when wild-type |mated females are mated to wild-type males. @146y146y@ mutant virgin |females show ovipositor extrusion towards courting wild-type males |(this extrusion behavior is normally observed in mated wild-type females |but not in virgin wild-type females). SYN|146y } } ALESR { ASYM|146y+ ID|FBal0151313 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0004951 CLA 1 repetitive element NAM 1 1.688 satellite-related 10Ea GSYM 1 1688-10Ea DT 1 16 Apr 05 RESZ 1081 DBA 3 WT 3 Euchromatic sequences of unknown function similar CLOC 1 10E1--2 REF 3 GSYM|1688-10Ea DT|16 Apr 05 ID|FBgn0004951 CLA|repetitive_element UAB|Deficiency: Df(1)HA85 (inferred from cytology) |Duplication: Dp(1;2)v+65b (inferred from cytology) SYN|1.688 |1688-10Ed NAM|1.688 satellite-related 10Ea GLOC|1-[36] CLOC|10E1--2 |Right limit from molecular mapping relative to 1688-10Eb (FBrf0057386) WT|Euchromatic sequences of unknown function similar, in their sequence, to |the 1.688 @satDNA@ repeat. It has been suggested (FBrf0057386) that they |may be required for some sex chromosome specific function. DBA|NA:X62938 |NA:Z50388 |dbSTS:24350 REF { REFM|FBrf0057386 |DiBartolomeis et al. |1992 |0 REFM|FBrf0080225 |Madueno et al. |1995 |0 REFM|FBrf0100592 |Law et al. |1998 |0 } REFDSR { RDID|FBrf0057386 |DiBartolomeis et al. |1992 OTH|The X linked SR sequences may be required for sex chromosome specific functions. } REFDSR { RDID|FBrf0080225 |Madueno et al. |1995 SYN|1.688 } } # EOR GENR { RETE|ID 1 FBgn0004952 CLA 1 repetitive element NAM 1 1.688 satellite-related 10Eb GSYM 1 1688-10Eb DT 1 16 Apr 05 RESZ 1274 DBA 3 WT 3 Euchromatic sequences of unknown function similar CLOC 1 10E1--2 REF 4 GSYM|1688-10Eb DT|16 Apr 05 ID|FBgn0004952 CLA|repetitive_element UAB|Deficiency: Df(1)HA85 (inferred from cytology) |Duplication: Dp(1;2)v+65b (inferred from cytology) SYN|1.688 |1688-10Ep NAM|1.688 satellite-related 10Eb GLOC|1-[36] CLOC|10E1--2 |Left limit from in situ hybridization (FBrf0057386) |Right limit from in situ hybridization (FBrf0057386) CYC|Experimentally determined: 10E1--2 WT|Euchromatic sequences of unknown function similar, in their sequence, to |the 1.688 @satDNA@ repeat. It has been suggested (FBrf0057386) that they |may be required for some sex chromosome specific function. DBA|NA:X62937 |NA:Z32192 |dbSTS:4743 REF { REFM|FBrf0057386 |DiBartolomeis et al. |1992 |0 REFM|FBrf0071734 |EDGP Project Members |1994- |9 REFM|FBrf0080225 |Madueno et al. |1995 |0 REFM|FBrf0100592 |Law et al. |1998 |0 } REFDSR { RDID|FBrf0057386 |DiBartolomeis et al. |1992 CLOC|10E1--2 (determined by in situ hybridization) OTH|The X linked SR sequences may be required for sex chromosome specific functions. } REFDSR { RDID|FBrf0080225 |Madueno et al. |1995 SYN|1.688 } } # EOR GENR { RETE|ID 1 FBgn0004953 CLA 1 repetitive element NAM 1 1.688 satellite-related 11EF GSYM 1 1688-11EF DT 1 16 Apr 05 RESZ 1034 WT 3 Euchromatic sequences of unknown function similar CLOC 1 11E--F REF 4 GSYM|1688-11EF DT|16 Apr 05 ID|FBgn0004953 CLA|repetitive_element UAB|Deficiency: Df(1)C246 (inferred from cytology) |Duplication: Dp(1;3)rasv (inferred from cytology) SYN|1.688 NAM|1.688 satellite-related 11EF GLOC|1-[41] CLOC|11E--F WT|Euchromatic sequences of unknown function similar, in their sequence, to |the 1.688 @satDNA@ repeat. It has been suggested (FBrf0057386) that they |may be required for some sex chromosome specific function. REF { REFM|FBrf0057386 |DiBartolomeis et al. |1992 |0 REFM|FBrf0047217 |Waring and Pollack |1987 |0 REFM|FBrf0080225 |Madueno et al. |1995 |0 REFM|FBrf0100592 |Law et al. |1998 |0 } REFDSR { RDID|FBrf0057386 |DiBartolomeis et al. |1992 OTH|The X linked SR sequences may be required for sex chromosome specific functions. } REFDSR { RDID|FBrf0080225 |Madueno et al. |1995 SYN|1.688 } } # EOR GENR { RETE|ID 1 FBgn0027098 CLA 1 repetitive element NAM 1 1688-2E GSYM 1 1688-2E DT 1 25 Nov 05 RESZ 197 DBA 1 REF 1 GSYM|1688-2E DT|25 Nov 05 ID|FBgn0027098 CLA|repetitive_element NAM|1688-2E DBA|NA:AJ238704 REF { REFM|FBrf0107580 |Alatortsev et al. |1998 |0 } } # EOR GENR { RETE|ID 1 FBgn0004950 CLA 1 repetitive element NAM 1 1.688 satellite-related 3C GSYM 1 1688-3C DT 1 16 Apr 05 RESZ 1236 DBA 3 WT 3 Euchromatic sequences of unknown function similar CLOC 1 3C REF 4 GSYM|1688-3C DT|16 Apr 05 ID|FBgn0004950 CLA|repetitive_element UAB|Deficiency: T(1;3)143-3 (inferred from cytology) |Duplication: Dp(1;Y)w+303 (inferred from cytology) SYN|1.688 NAM|1.688 satellite-related 3C GLOC|1-[1.5] CLOC|3C |Left limit from in situ hybridization (FBrf0057386) |Right limit from in situ hybridization (FBrf0057386) CYC|Experimentally determined: 3C WT|Euchromatic sequences of unknown function similar,